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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-OSTM1 Antibody (8U899)

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货号 TMAY-01322

别名 osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik

Anti-OSTM1 Antibody (8U899) 是一种 Mouse 抗体，靶向 OSTM1。Anti-OSTM1 Antibody (8U899) 可用于 ELISA。

Anti-OSTM1 Antibody (8U899)

Anti-OSTM1 Antibody (8U899)

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货号 TMAY-01322 别名 osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik

Anti-OSTM1 Antibody (8U899) 是一种 Mouse 抗体，靶向 OSTM1。Anti-OSTM1 Antibody (8U899) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 1,694
5日内发货
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产品介绍

生物活性
产品描述
Anti-OSTM1 Antibody (8U899) is a Mouse antibody targeting OSTM1. Anti-OSTM1 Antibody (8U899) can be used in ELISA.
别名osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik
Ig Type
Mouse IgG1
克隆号
8U899
反应种属
Human
特异性
Human OSTM1
No cross-reactivity in ELISA with
Human cell lysate (293 cell line)
应用ELISA
推荐剂量
ELISA: 1:1000-1:2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human OSTM1 (rh OSTM1; TMPY-01194; NP_054747.2; Met 1-Pro 284). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has an important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrosis phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human OSTM1 protein (TMPY-01194)
抗原种属
Human
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.
存储-20°C for 1 year

计算器

  • 稀释 计算器

关键词

HSPC-019HSPC 019
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