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Anti-OSTM1 Antibody (8U899)
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产品编号 TMAY-01322
别名 osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik
Anti-OSTM1 Antibody (8U899) 是一种 Mouse 抗体，靶向 OSTM1。Anti-OSTM1 Antibody (8U899) 可用于 ELISA。
Anti-OSTM1 Antibody (8U899)
Anti-OSTM1 Antibody (8U899)
还可以产品编号 TMAY-01322 别名 osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik
Anti-OSTM1 Antibody (8U899) 是一种 Mouse 抗体，靶向 OSTM1。Anti-OSTM1 Antibody (8U899) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,694 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-OSTM1 Antibody (8U899) is a Mouse antibody targeting OSTM1. Anti-OSTM1 Antibody (8U899) can be used in ELISA. |
| 别名 | osteopetrosis associated transmembrane protein 1, HSPC019, gl, 1200002H13Rik |
| Ig Type | Mouse IgG1 |
| 克隆号 | 8U899 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human OSTM1 (rh OSTM1; TMPY-01194; NP_054747.2; Met 1-Pro 284). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has an important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrosis phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO). |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human OSTM1 protein (TMPY-01194) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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