Anti-USP7 Antibody (5F63)

Name: Anti-USP7 Antibody (5F63)
Brand: TargetMol
SKU: TMAY-01987
Rating: 4.5 (1 reviews)

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产品编号 TMAY-01987

别名 ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP

Anti-USP7 Antibody (5F63) 是一种 Mouse 抗体，靶向 USP7。Anti-USP7 Antibody (5F63) 可用于 ELISA。

Anti-USP7 Antibody (5F63)

还可以

产品编号 TMAY-01987 别名 ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP

Anti-USP7 Antibody (5F63) 是一种 Mouse 抗体，靶向 USP7。Anti-USP7 Antibody (5F63) 可用于 ELISA。

规格	价格	库存	数量
100 μL	¥ 1,679	5日内发货

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生物活性

产品描述	Anti-USP7 Antibody (5F63) is a Mouse antibody targeting USP7. Anti-USP7 Antibody (5F63) can be used in ELISA.
别名	ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP
Ig Type	Monoclonal Mouse IgG2b
克隆号	5F63
交叉反应	Human
应用	ELISA
推荐剂量	ELISA: 1:1000-1:2000
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human USP7 / HAUSP (rh USP7 / HAUSP; TMPY-01463; Lys 208-Glu 560; NP_003461.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein that belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP stimulates lytic infection and the reactivation of quiescent viral genomes. ICP interacts very strongly with USP7. USP7-mediated stabilization of ICP is dominant over ICP-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP are expressed.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Human USP7 / HAUSP Protein (TMPY-01463)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.