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Anti-STUB1 Antibody (3E854)
还可以产品编号 TMAY-02371
Anti-STUB1 Antibody (3E854) 是一种 Rabbit 抗体，靶向 STUB1。Anti-STUB1 Antibody (3E854) 可用于 IHC-P。
Anti-STUB1 Antibody (3E854)
Anti-STUB1 Antibody (3E854)
还可以产品编号 TMAY-02371
Anti-STUB1 Antibody (3E854) 是一种 Rabbit 抗体，靶向 STUB1。Anti-STUB1 Antibody (3E854) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-STUB1 Antibody (3E854) is a Rabbit antibody targeting STUB1. Anti-STUB1 Antibody (3E854) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 3E854 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human STUB1 in human skeletal muscle with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human STUB1 in human placenta with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human STUB1 in human pancreas with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human STUB1 isoform 1 (Q9UNE7-1; Met 1-Tyr 303). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CHIP, the protein encoded by STUB1, is a central component of cellular protein homeostasis and interacts with several key proteins involved in the pathogenesis of manifold neurodegenerative diseases. Missense and truncating mutations in STUB1 lead to SCAR16. CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer. Pathogenic variants in STUB1 were initially described in autosomal recessive spinocerebellar ataxia type 16 and dominant cerebellar ataxia with cerebellar cognitive dysfunction (SCA48). Data indicated that STUB1 deficiency leads both to the intracellular accumulation of protein aggregates and to an increase in the secretion of small extracellular vesicles (sEVs), including exosomes. Secreted sEVs are enriched in ubiquitinated and/or undegraded proteins and protein oligomers. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human STUB1 protein |
| 抗原种属 | Human |
| 研究领域 | Adaptor Proteins |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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