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LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated

LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated

产品编号 TMPJ-00179
别名: hLAIR1, LAIR-1, LAIR1, CD305, Leukocyte-Associated Immunoglobulin-Like Receptor 1

LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is Q6GTX8.

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LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated
规格 价格/CNY 货期 数量
20 μg ¥ 2,260 5日内发货
100 μg ¥ 6,130 5日内发货
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产品目录号及名称: LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated (TMPJ-00179)
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产品描述 LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is Q6GTX8.
种属 Human
表达系统 HEK293 Cells
标签 C-Avi-6xHis
蛋白编号 Q6GTX8
别名 hLAIR1, LAIR-1, LAIR1, CD305, Leukocyte-Associated Immunoglobulin-Like Receptor 1
氨基酸序列 Gln22-His163
蛋白构建 Gln22-His163
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 30-35 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.2.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.

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Keywords

LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated hLAIR1 LAIR 1 LAIR-1 CD 305 CD-305 LAIR1 CD305 Leukocyte-Associated Immunoglobulin-Like Receptor 1 recombinant recombinant-proteins proteins protein

 

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