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Anti-Mucin-1/MUC1 Antibody (4U345)
还可以产品编号 TMAY-02245
Anti-Mucin-1/MUC1 Antibody (4U345) 是一种 Mouse 抗体，靶向 Mucin-1/MUC1。Anti-Mucin-1/MUC1 Antibody (4U345) 可用于 ELISA,IHC-P。
Anti-Mucin-1/MUC1 Antibody (4U345)
Anti-Mucin-1/MUC1 Antibody (4U345)
还可以产品编号 TMAY-02245
Anti-Mucin-1/MUC1 Antibody (4U345) 是一种 Mouse 抗体，靶向 Mucin-1/MUC1。Anti-Mucin-1/MUC1 Antibody (4U345) 可用于 ELISA,IHC-P。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Mucin-1/MUC1 Antibody (4U345) is a Mouse antibody targeting Mucin-1/MUC1. Anti-Mucin-1/MUC1 Antibody (4U345) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4U345 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human MUC1 in human breast carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human MUC1 in human ovarian cancer with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human MUC1 in human breast with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | ELISA,IHC-P |
| 推荐剂量 | ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MUC1/Mucin 1/CD227 (rh MUC1/Mucin 1/CD227; TMPY-02871; NP_001018016.1; Met1-Gly167). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Mucin 1, cell surface-associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach, and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized, and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC, and NF-kappa-B pathways. In the activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human MUC1/Mucin 1/CD227 Protein (TMPY-02871) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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