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Anti-TROP-2 Antibody-HRP (7D257) 是一种 HRP-conjugated Mouse 抗体,靶向 TROP-2。Anti-TROP-2 Antibody-HRP (7D257) 可用于 ELISA。
Anti-TROP-2 Antibody-HRP (7D257) 是一种 HRP-conjugated Mouse 抗体,靶向 TROP-2。Anti-TROP-2 Antibody-HRP (7D257) 可用于 ELISA。
产品描述 | Anti-TROP-2 Antibody-HRP (7D257) is a HRP-conjugated Mouse antibody targeting TROP-2. Anti-TROP-2 Antibody-HRP (7D257) can be used in ELISA. |
Ig Type | Monoclonal Mouse IgG1 |
克隆号 | 7D257 |
交叉反应 | Human |
应用 | ELISA |
推荐剂量 | ELISA: 0.1-1 μg/ml |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TROP2 extracellular domain (rh TROP2; TMPY-01262; NP_002344.2; Met 1-Thr 274). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. |
偶联 | HRP |
其他可选修饰符 | Unconjugated/Biotin/FITC/PE |
可提供抗体种类 | 5 |
免疫原 | Recombinant Human TROP2 protein (TMPY-01262) |
抗原种属 | Human |
研究领域 | Cancer Drug Targets |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
运输方式 | Shipping with blue ice. |
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