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Anti-CASPR2 Antibody (4V558) 是一种 Rabbit 抗体,靶向 CASPR2。Anti-CASPR2 Antibody (4V558) 可用于 ELISA。
Anti-CASPR2 Antibody (4V558) 是一种 Rabbit 抗体,靶向 CASPR2。Anti-CASPR2 Antibody (4V558) 可用于 ELISA。
产品描述 | Anti-CASPR2 Antibody (4V558) is a Rabbit antibody targeting CASPR2. Anti-CASPR2 Antibody (4V558) can be used in ELISA. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 4V558 |
交叉反应 | Mouse |
应用 | ELISA |
推荐剂量 | ELISA: 1:5000-1:10000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CNTNAP2 / CASPR2 (rM CNTNAP2 / CASPR2; TMPY-01695; NP_001004357.2; Met 1-Ser 1262). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This protein encoding gene is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. CNTNAP2/CASPR2 may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2/CASPR2 Seems to demarcate the juxtaparanodal region of the axo-glial junction. |
偶联 | Unconjugated |
免疫原 | Recombinant Mouse CNTNAP2 / CASPR2 protein (TMPY-01695) |
抗原种属 | Mouse |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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