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EGFR

EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T11157L EGFR-IN-1 hydrochloride
EGFR-IN-1盐酸盐
2227455-78-7 98%
EGFR-IN-1 hydrochloride 是 L858R/T790M 突变体 EGFR 的不可逆特异性抑制剂,选择性是野生型 EGFR 的 100 倍。 EGFR-IN-1 hydrochloride 在 H1975 细胞和突变体 HCC827 细胞中表现出有效的抗肿瘤和抗增殖活性,IC50 分别为 4 和 28 ...
T34656 SKLB 1028
化合物Ruserontinib
1350544-93-2 98%
SKLB1028是口服活性的、新型的EGFR、FLT3和Abl 多激酶抑制剂。SKLB1028在FLT3驱动的AML 模型中显示出优异的活性,在含有Abl 突变体的CML 模型中显示了相当大的效力
T68113 Naluzotan hydrochloride
Naluzotan盐酸盐
740873-82-9 98%
Naluzotan hydrochloride 是一种小分子、非氮杂吡酮、5-羟色胺(5-HT)1A 受体激动剂和sigma-1受体拮抗剂。在之前的临床试验中,该化合物在400多名患者中被证明安全且耐受性良好。
T14077 A-935142
化合物A-935142
1031335-85-9 98%
A-935142是一种人类醚-a-go-go 相关基因(hERG,Kv 11.1)通道激活剂。A-935142通过减慢失活、促进激活、减少失活、缩短心房和心室复极化,并通过一种复杂的方式增强 hERG 电流。
T2610 BMS-599626
化合物BMS 599626
714971-09-2 98%
BMS-599626 是可口服的选择性 HER1和HER2抑制剂,IC50分别为 20 和 30 nM。它对 HER4 的 IC50值为 190 nM,可抑制肿瘤细胞增殖,有治疗肿瘤的潜力。
T2460 JAK 3 inhibitor IV
化合物JAK 3 inhibitor IV
58753-54-1 98%
JAK 3 inhibitor IV 是一种 JAK1/3 抑制剂,pIC50 为 4.4/7.1,对 JAK2 几乎没有活性,对 EGFR 有适度的作用;还发现对转谷氨酰胺酶敏感。
T12175 Naquotinib mesylate
化合物Naquotinib mesylate
1448237-05-5 98%
Naquotinib mesylate 是一种口服的、突变体选择性和不可逆的 EGFR 抑制剂,对 EGFR 突变体和 EGFR 的 IC50值分别为8-33和230 nM。
T3P2855 Chamigrenal
恰米醛
19912-84-6 98%
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
T13559 Astragaloside VI
化合物 T13559
84687-45-6 98%
Astragaloside VI could improve wound healing by activating the EGFR/ERK signaling pathway.
T14677 BMS-690514
化合物BMS-690514
859853-30-8 98%
BMS-690514是可口服的EGFR 和VEGFR 抑制剂,对于EGFR、HER2和HER4的IC50值分别为5、9 和 60 nM。
TN3042 4-Hydroxycinnamamide
化合物 TN3042
194940-15-3 98%
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
T11164 EGFR mutant-IN-1
化合物 T11164
T11164 98%
EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantl...
T15621 Rilematovir
化合物Rilematovir
1383450-81-4 98%
Rilematovir 是一种融合蛋白抑制剂,具有抗病毒活性和低细胞毒性。 Rilematovir 可用于呼吸道合胞病毒治疗的研究。
T11157 EGFR-IN-1
化合物 T11157
1625677-63-5 98%
EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. EGFR-IN-1 is an orally a...
TQ0293 AV-412 free base
无盐AV-412
451492-95-8 98%
AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).
TMA1944 Protopine hydrochloride
化合物 TMA1944
6164-47-2 98%
Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracell...
T6046 CP-724714
化合物CP-724714
537705-08-1 98%
(E/Z)-CP-724714 是 (E)-CP-724714 和 (Z)-CP-724714 的外消旋体。CP-724714是一种高效、选择性的口服活性的 ErbB2 (HER2) 酪氨酸激酶抑制剂。
TN3525 Boehmenan
化合物 TN3525
57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T10256 Afatinib D6
化合物 T10256
1313874-96-2 98%
Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.
TN1871 Ligustroside
女贞甙
35897-92-8 98%
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
EGFR-IN-1 hydrochloride
T11157L
EGFR-IN-1 hydrochloride 是 L858R/T790M 突变体 EGFR 的不可逆特异性抑制剂,选择性是野生型 EGFR 的 100 倍。 EGFR-IN-1 hydrochloride 在 H1975 细胞和突变体 HCC827 细胞中表现出有效的抗肿瘤和抗增殖活性,IC50 分别为 4 和 28 ...
SKLB 1028
T34656
SKLB1028是口服活性的、新型的EGFR、FLT3和Abl 多激酶抑制剂。SKLB1028在FLT3驱动的AML 模型中显示出优异的活性,在含有Abl 突变体的CML 模型中显示了相当大的效力
Naluzotan hydrochloride
T68113
Naluzotan hydrochloride 是一种小分子、非氮杂吡酮、5-羟色胺(5-HT)1A 受体激动剂和sigma-1受体拮抗剂。在之前的临床试验中,该化合物在400多名患者中被证明安全且耐受性良好。
A-935142
T14077
A-935142是一种人类醚-a-go-go 相关基因(hERG,Kv 11.1)通道激活剂。A-935142通过减慢失活、促进激活、减少失活、缩短心房和心室复极化,并通过一种复杂的方式增强 hERG 电流。
BMS-599626
T2610
BMS-599626 是可口服的选择性 HER1和HER2抑制剂,IC50分别为 20 和 30 nM。它对 HER4 的 IC50值为 190 nM,可抑制肿瘤细胞增殖,有治疗肿瘤的潜力。
JAK 3 inhibitor IV
T2460
JAK 3 inhibitor IV 是一种 JAK1/3 抑制剂,pIC50 为 4.4/7.1,对 JAK2 几乎没有活性,对 EGFR 有适度的作用;还发现对转谷氨酰胺酶敏感。
Naquotinib mesylate
T12175
Naquotinib mesylate 是一种口服的、突变体选择性和不可逆的 EGFR 抑制剂,对 EGFR 突变体和 EGFR 的 IC50值分别为8-33和230 nM。
Chamigrenal
T3P2855
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
Astragaloside VI
T13559
Astragaloside VI could improve wound healing by activating the EGFR/ERK signaling pathway.
BMS-690514
T14677
BMS-690514是可口服的EGFR 和VEGFR 抑制剂,对于EGFR、HER2和HER4的IC50值分别为5、9 和 60 nM。
4-Hydroxycinnamamide
TN3042
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
EGFR mutant-IN-1
T11164
EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantl...
Rilematovir
T15621
Rilematovir 是一种融合蛋白抑制剂,具有抗病毒活性和低细胞毒性。 Rilematovir 可用于呼吸道合胞病毒治疗的研究。
EGFR-IN-1
T11157
EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. EGFR-IN-1 is an orally a...
AV-412 free base
TQ0293
AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).
Protopine hydrochloride
TMA1944
Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracell...
CP-724714
T6046
(E/Z)-CP-724714 是 (E)-CP-724714 和 (Z)-CP-724714 的外消旋体。CP-724714是一种高效、选择性的口服活性的 ErbB2 (HER2) 酪氨酸激酶抑制剂。
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
Afatinib D6
T10256
Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.
Ligustroside
TN1871
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
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