EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product Name	CAS No.	Purity
T11157L	EGFR-IN-1 hydrochloride EGFR-IN-1盐酸盐	2227455-78-7	98%
T11157L	EGFR-IN-1 hydrochloride 是 L858R/T790M 突变体 EGFR 的不可逆特异性抑制剂，选择性是野生型 EGFR 的 100 倍。 EGFR-IN-1 hydrochloride 在 H1975 细胞和突变体 HCC827 细胞中表现出有效的抗肿瘤和抗增殖活性，IC50 分别为 4 和 28 ...
T34656	SKLB 1028 化合物Ruserontinib	1350544-93-2	98%
T34656	SKLB1028是口服活性的、新型的EGFR、FLT3和Abl 多激酶抑制剂。SKLB1028在FLT3驱动的AML 模型中显示出优异的活性，在含有Abl 突变体的CML 模型中显示了相当大的效力
T68113	Naluzotan hydrochloride Naluzotan盐酸盐	740873-82-9	98%
T68113	Naluzotan hydrochloride 是一种小分子、非氮杂吡酮、5-羟色胺(5-HT)1A 受体激动剂和sigma-1受体拮抗剂。在之前的临床试验中，该化合物在400多名患者中被证明安全且耐受性良好。
T14077	A-935142 化合物A-935142	1031335-85-9	98%
T14077	A-935142是一种人类醚-a-go-go 相关基因（hERG，Kv 11.1）通道激活剂。A-935142通过减慢失活、促进激活、减少失活、缩短心房和心室复极化，并通过一种复杂的方式增强 hERG 电流。
T2610	BMS-599626 化合物BMS 599626	714971-09-2	98%
T2610	BMS-599626 是可口服的选择性 HER1和HER2抑制剂，IC50分别为 20 和 30 nM。它对 HER4 的 IC50值为 190 nM，可抑制肿瘤细胞增殖，有治疗肿瘤的潜力。
T2460	JAK 3 inhibitor IV 化合物JAK 3 inhibitor IV	58753-54-1	98%
T2460	JAK 3 inhibitor IV 是一种 JAK1/3 抑制剂，pIC50 为 4.4/7.1，对 JAK2 几乎没有活性，对 EGFR 有适度的作用；还发现对转谷氨酰胺酶敏感。
T12175	Naquotinib mesylate 化合物Naquotinib mesylate	1448237-05-5	98%
T12175	Naquotinib mesylate 是一种口服的、突变体选择性和不可逆的 EGFR 抑制剂，对 EGFR 突变体和 EGFR 的 IC50值分别为8-33和230 nM。
T3P2855	Chamigrenal 恰米醛	19912-84-6	98%
T3P2855	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
T13559	Astragaloside VI 化合物 T13559	84687-45-6	98%
T13559	Astragaloside VI could improve wound healing by activating the EGFR/ERK signaling pathway.
T14677	BMS-690514 化合物BMS-690514	859853-30-8	98%
T14677	BMS-690514是可口服的EGFR 和VEGFR 抑制剂，对于EGFR、HER2和HER4的IC50值分别为5、9 和 60 nM。
TN3042	4-Hydroxycinnamamide 化合物 TN3042	194940-15-3	98%
TN3042	4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
T11164	EGFR mutant-IN-1 化合物 T11164	T11164	98%
T11164	EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantl...
T15621	Rilematovir 化合物Rilematovir	1383450-81-4	98%
T15621	Rilematovir 是一种融合蛋白抑制剂，具有抗病毒活性和低细胞毒性。 Rilematovir 可用于呼吸道合胞病毒治疗的研究。
T11157	EGFR-IN-1 化合物 T11157	1625677-63-5	98%
T11157	EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. EGFR-IN-1 is an orally a...
TQ0293	AV-412 free base 无盐AV-412	451492-95-8	98%
TQ0293	AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).
TMA1944	Protopine hydrochloride 化合物 TMA1944	6164-47-2	98%
TMA1944	Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracell...
T6046	CP-724714 化合物CP-724714	537705-08-1	98%
T6046	(E/Z)-CP-724714 是 (E)-CP-724714 和 (Z)-CP-724714 的外消旋体。CP-724714是一种高效、选择性的口服活性的 ErbB2 (HER2) 酪氨酸激酶抑制剂。
TN3525	Boehmenan 化合物 TN3525	57296-22-7	98%
TN3525	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T10256	Afatinib D6 化合物 T10256	1313874-96-2	98%
T10256	Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.
TN1871	Ligustroside 女贞甙	35897-92-8	98%
TN1871	Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...