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SU 4313

Name: SU 4313
Brand: TargetMol
SKU: T3568
Price: 256 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.89%

货号 T3568Cas号 186611-55-2

SU 4313 是一种生物活性化学品。

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SU 4313

一键复制产品信息

很棒

纯度: 99.89%

货号 T3568Cas号 186611-55-2

SU 4313 是一种生物活性化学品。

规格	价格	库存
1 mg	¥ 256	现货
5 mg	¥ 596	现货
10 mg	¥ 932	现货
25 mg	¥ 1,630	现货
50 mg	¥ 2,380	现货
100 mg	¥ 3,530	现货
200 mg	¥ 4,950	现货
1 mL x 10 mM (in DMSO)	¥ 597	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

SU 4313 AI Summary

SU 4313 exhibits inhibitory activity against multiple receptors and enzymes. It inhibits vascular endothelial growth factor receptor 2 (VEGFR2 or FLK1) with an IC50 value of 5248.07 nM. Additionally, it inhibits tyrosine phosphorylation on several receptors, including human Platelet-derived growth factor receptor beta (IC50 = 24200.0 nM), murine VEGF receptor (IC50 = 5200.0 nM), human Epidermal growth factor receptor (IC50 = 18500.0 nM), human Her-2 receptor tyrosine kinase (IC50 = 16900.0 nM), and human Insulin-like growth factor I receptor (IC50 = 10000.0 nM). SU 4313 also shows significant inhibitory activity against AmpC beta-Lactamase with an IC50 of 6000.0 nM, and against beta-Lactamase, displaying 95.0% inhibition at 20 uM in the absence of detergent Triton X-100, which drops to 27.0% in the presence of 0.01% Triton X-100. It further inhibits chymotrypsinogen, cloned Dihydrofolate reductase (cDHFR), and Beta-galactosidase, with IC50 values of 30000.0 nM, 30000.0 nM, and 55000.0 nM respectively. Notably, the compound forms aggregates as observed by dynamic light scattering at a concentration of 10.0 uM, and its inhibitory activity is influenced by varying potassium phosphate buffer concentrations, with IC50 values ranging from 3000.0 nM to 7000.0 nM. SU 4313 also shows improved inhibitory activity against beta-lactamase when preincubated, leading to a fold decrease in IC50..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SU 4313 is a bioactive chemical.
靶点活性	PDGFR:14.5 μM, IGF-1R:8.0 μM, FLK1:18.8 μM, EGFR:11 μM, HER2:16.9 μM

化学信息

分子量	263.33
分子式	C₁₈H₁₇NO
CAS No.	186611-55-2
Smiles	C(=C1C=2C(NC1=O)=CC=CC2)C3=CC=C(C(C)C)C=C3
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 65 mg/mL (246.84 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 5 mg/mL (18.99 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7975 mL	18.9876 mL	37.9752 mL	189.8758 mL
5 mM	0.7595 mL	3.7975 mL	7.5950 mL	37.9752 mL
10 mM	0.3798 mL	1.8988 mL	3.7975 mL	18.9876 mL
20 mM	0.1899 mL	0.9494 mL	1.8988 mL	9.4938 mL
50 mM	0.0760 mL	0.3798 mL	0.7595 mL	3.7975 mL
100 mM	0.0380 mL	0.1899 mL	0.3798 mL	1.8988 mL