HER2-IN-16 (Compound 14) is a HER2 inhibitor that effectively suppresses the YVMA HER2 exon 20 insertion mutation (HER2 YVMA) with an IC50 of less than 200 nM. It also inhibits the proliferation of HER2 YVMA mutant BaF3 cells with an IC50 below 200 nM and shows potential in improving non-small cell lung cancer (NSCLC).

Her2 exon 20 YVMA insertion:<200 nM