Name: AFM24
Brand: TargetMol
SKU: T9901A-513
Price: 2900 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,900

现货

5 mg

¥ 7,880

现货

10 mg

¥ 12,300

现货

生物活性

产品描述	AFM24 is a bispecific antibody with a TandAb structure expressed in CHO cells, simultaneously targeting the Epidermal Growth Factor Receptor (EGFR) and FcγRIIIA (CD16A). It consists of a huIgG1-scFv heavy chain and a λ light chain, with a predicted molecular weight of 196.34 kDa. As a novel innate immune cell engager, AFM24 binds with high affinity to CD16A on NK cells and macrophages, directing these effector cells to eliminate EGFR-positive tumor cells. Its mechanism primarily leverages enhanced antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) to overcome limitations of conventional anti-EGFR therapies.
体外活性	AFM24 能高亲和力结合 EGFR 与 CD16A，诱导 NK 细胞对 EGFR 阳性肿瘤细胞产生强效细胞毒性。其作用不依赖 EGFR 信号阻断，故对 KRAS/BRAF 突变耐药肿瘤依然有效。此外，它还能介导巨噬细胞对肿瘤细胞的吞噬作用 (ADCP) [1]。
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal, Bispecific
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量

150 kDa

储存&溶解度

存储	Store at -20°C Shipping with blue ice. 实际储存温度请以COA为准

AFM24