Name: Amivantamab
Brand: TargetMol
SKU: T9901A-1551
Rating: 4.5 (1 reviews)

生物活性

产品描述	Amivantamab (JNJ-61186372) is a humanized antibody that recognizes epidermal growth factor receptor (EGFR) and MET proto-oncogene (MET), with anticancer and anti-tumor activities, preventing ligand binding to EGFR and MET and receptor dimerization that inhibits downstream signal transduction. Amivantamab can induce Fc-dependent endocytosis of macrophages and antibody-dependent cytotoxicity of natural killer cells, and can be used to study metastatic non-small cell lung cancer.
体外活性	用0.05至1 mg/mL 的 Amivantamab 处理 Ba/F3 细胞时，在所有五种表皮生长因子受体 Exon20ins 突变中都观察到了 Ba/F3 细胞活力的显著下降，且呈剂量依赖性（P < 0.0001）。[1]
体内活性	小鼠每周两次腹腔注射 30 mg/kg 的 Amivantamab 、IgG1 对照组或溶剂对照。经 Amivantamab 治疗的小鼠在Ba/F3细胞携带 NOD 的情况下肿瘤体积缩小。[1]
别名	埃万妥单抗, JNJ-61186372, JNJ61186372
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
内毒素	＜ 1.0 EU/mg

偶联与修饰

偶联	Unconjugated

抗原信息

靶点	c-Met/EGFR

化学信息

分子量	145.9 kDa
CAS No.	2171511-58-1

储存&溶解度

存储	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Amivantamab