Name: Trastuzumab emtansine
Brand: TargetMol
SKU: T36647
Price: 3980 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 3,980

现货

5 mg

¥ 8,460

现货

10 mg

¥ 11,300

现货

25 mg

¥ 16,900

现货

50 mg

¥ 22,800

现货

生物活性

产品描述	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody–drug conjugate that combines the HER2-targeted antitumor specificity of trastuzumab with the potent cytotoxic activity of the microtubule inhibitor DM1, Trastuzumab emtansine enables selective intracellular delivery of the cytotoxic payload to HER2-expressing cells and supporting translational and mechanistic research in advanced breast cancer models.
体外活性	Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2].
体内活性	方法：在注射 OVA10 细胞的 CB-17/SCID 小鼠中，每周静脉注射Trastuzumab emtansine15 mg/kg，每周 3–5 次，持续 3 周。结果：Trastuzumab emtansine在肿瘤负荷小鼠中产生显著的抗肿瘤效果[2]。
别名	恩美曲妥珠单抗, Trastuzumab emtansine, T-DM1
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

抗原信息

Uniprot ID	P04626
靶点	HER2

化学信息

储存&溶解度

存储
溶解度信息	DMSO: 160 mg/mL, Sonication is recommended.

Trastuzumab emtansine