Name: Pimurutamab
Brand: TargetMol
SKU: T80612
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

待询

5 mg

待询

生物活性

产品描述	Pimurutamab (HLX-07) is a glycoengineered humanized IgG1 monoclonal antibody that specifically targets the Epidermal Growth Factor Receptor (EGFR/HER1). By binding to the extracellular domain of EGFR, Pimurutamab blocks ligand (e.g., EGF, TGF-α) binding, inhibiting receptor dimerization and downstream signaling cascades (e.g., RAS/RAF/MEK/ERK). Its optimized glycosylation profile significantly enhances Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) activity. Pimurutamab is developed for treating EGFR-overexpressing solid tumors, such as colorectal cancer and head and neck squamous cell carcinoma, with potentially improved efficacy over cetuximab.
体外活性	在利用人癌细胞系开展的巨噬细胞吞噬实验中，Pimurutamab (ATG-031)（纳摩尔浓度）阻断了 CD24-Siglec-10 的相互作用，并显著增强了对肿瘤细胞的吞噬作用 [1]。
体内活性	在人源肿瘤异种移植模型中，通过全身给药方式给予 Pimurutamab (ATG-031)，实验结果显示其显著抑制了肿瘤生长，并在联用 PD-L1 抑制剂时表现出协同效应 [1]。
别名	匹姆瑞妥单抗
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P00533
靶点	EGFR

化学信息

CAS No.

2251771-76-1

储存&溶解度

存储	store at low temperature \| store at -20°C \| Shipping with blue ice/Shipping at ambient temperature.

Pimurutamab