Name: Petosemtamab
Brand: TargetMol
SKU: T76890
Price: 2480 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,480

现货

5 mg

¥ 5,860

现货

生物活性

产品描述	Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab can be used in the study of solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).
靶点活性	EGFR:0.22 nM (Kd), LGR5:0.85 nM (Kd)
体外活性	处理MCLA-158(Petosemtamab)（1 µg/mL；24或72小时）在EGFR+/LGR5+结直肠癌类器官中诱导EGFR的降解[2]。
体内活性	使用MCLA-158(Petosemtamab)（每周25 mg/kg，静脉注射，持续6周）治疗可导致食管鳞状细胞癌、胃腺癌以及头颈部PDX模型中的肿瘤退缩[2]。
别名	派森妥单抗, MCLA 158
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
内毒素	< 1 EU/mg as determined by the LAL method

抗体信息

同型	Human IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

储存&溶解度

存储	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Petosemtamab