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Hersintuzumab 是一种针对人表皮生长因子受体 2 (HER2/ErbB2) 的人源化单克隆抗体。该抗体通过特异性结合 HER2 胞外域,阻断下游的增殖信号通路(如 PI3K/Akt)并介导抗体依赖性细胞毒作用 (ADCC),被广泛用于研究乳腺癌、胃癌等 HER2 阳性恶性肿瘤的治疗策略。
Hersintuzumab 是一种针对人表皮生长因子受体 2 (HER2/ErbB2) 的人源化单克隆抗体。该抗体通过特异性结合 HER2 胞外域,阻断下游的增殖信号通路(如 PI3K/Akt)并介导抗体依赖性细胞毒作用 (ADCC),被广泛用于研究乳腺癌、胃癌等 HER2 阳性恶性肿瘤的治疗策略。

| 产品描述 | Hersintuzumab is a humanized monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER2/ErbB2). By specifically binding to the extracellular domain of HER2, it blocks downstream proliferative signaling pathways (e.g., PI3K/Akt) and mediates antibody-dependent cellular cytotoxicity (ADCC), making it widely used to research therapeutic strategies for HER2-positive malignancies like breast and gastric cancers. |
| 反应种属 | Human |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 缓冲液 | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| 内毒素 | <1.0 EU/mg |
| 同型 | IgG1 |
| 偶联 | Unconjugated |
| Uniprot ID | |
| 靶点 | ERBB2/HER2/CD340 |
| 存储 |
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