CDX-3379 is a humanized monoclonal antibody inhibitor that targets ErbB3. By binding to ErbB3, CDX-3379 prevents its dimerization with other receptors, thus inhibiting ErbB3 phosphorylation. This compound can also inhibit the growth and proliferation of tumor cells. CDX-3379 shows potential for research in tumors expressing ErbB3 and NRG1, such as those found in HNSCC.