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Search Results for " pd-1 "

Targets Recommended: PD-1/PD-L1 PD-1/PD-L1

255

抑制剂 & 化合物

3

天然产物

3

化合物库

1819

重组蛋白

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Cat. No.	Product Name
L9830	抗帕金森病化合物库		857 compounds
	857 种帕金森病相关的化合物集合，可用于高通量和高内涵筛选；
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

抗帕金森病化合物库

Cat.No: L9830

Compounds: 857

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

Cat. No.	Product Name	Target	Signaling Pathways
T9651	PD-1/PD-L1-IN-9	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-9 是一种有效和具有口服活性的 PD-1/PD-L1 相互作用抑制剂，IC50 值为 3.8 nM。PD-1/PD-L1-IN-9 可以增强免疫细胞对肿瘤细胞的杀伤活性。PD-1/PD-L1-IN-9 在 CT26 小鼠模型中表现出显着的体内抗肿瘤活性。
T9616	PD-1/PD-L1-IN-10	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM)，显示出抗肿瘤活性。
T12379	PD-1-IN-22	Others; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Others
	PD-1-IN-22 是一种有效的程序性细胞死亡 1 (PD-1)/程序性细胞死亡配体1 (PD-L1) 相互作用的抑制剂，IC50 为 92.3 nM。
T35394	Sintilimab (anti-PD-1) IBI308,Sintilimab (anti-PD-1)	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Sintilimab (IBI308) 是一种人源化的 IgG4 单克隆抗体，具有显著的抗肿瘤活性，通过与 PD-1 结合从而阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用，进而恢复内源性抗肿瘤 T 细胞反应。Sintilimab 联合其他化合物来治疗经典霍奇金淋巴瘤、非小细胞肺癌和食管癌。
T3655	BMS-1 PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1	Apoptosis; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1 (PD-1/PD-L1 inhibitor 1)是一种 PD-1/PD-L1蛋白质/蛋白质相互作用的抑制剂，IC50为 6 到 100 nM。
T36899	INCB086550 PD-1/PD-L1-IN-8	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	INCB086550 (PD-1/PD-L1-IN-8) (example 24) 是 PD-1/PD-L1 的抑制剂，其IC50 值为 <= 10 nM。
T36900	PD-1/PD-L1-IN-NP19 PD-1/PD-L1-IN-NP19	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-NP19 是 PD-1/PD-L1 的抑制剂，抑制人类 PD-1/PD-L1 相互作用的 IC50 值为 12.5 nM。PD-1/PD-L1-IN-NP19 可以激活肿瘤的免疫微环境，这可能有助于其抗肿瘤作用。
T36487	Evixapodlin PD-1/PD-L1-IN 7,GS-4224	Antiviral; HBV; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Microbiology/Virology
	Evixapodlin (PD-1/PD-L1-IN 7) 是一种人 PD-1/PD-L1蛋白/蛋白相互作用抑制剂(IC50：0.213)。Evixapodlin 具有抗癌和抗病毒活性。
T40112	PROTAC PD-1/PD-L1 degrader-1 PROTAC PD-1/PD-L1 degrader-1
	PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
T5410	PD158780	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD158780是一种EGFR 家族抑制剂，对EGFR、ErbB2、ErbB3和ErbB4的IC50值分别为8 μM、49、52 和 52 nM。
T4696	BMS202 hydrochloride (1675203-84-5(free base)) PD-1/PD-L1 inhibitor 2 hydrochloride	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS202 hydrochloride (1675203-84-5(free base)) (PD-1/PD-L1 inhibitor 2 hydrochloride) 是一种小分子 PD-1/PD-L1 相互作用抑制剂 (IC50: 18 nM)。生物物理研究表明 BMS202 直接与 PD-L1 结合。 BMS202 的结合促进 PD-L1 二聚化并阻断 PD-L1/PD1 相互作用。
T12380	PD-1/PD-L1-IN 5 TFA PD-1/PD-L1-IN 5	Others	Others
	PD-1/PD-L1-IN 5 is an inhibitor of PD-1/PD-L1 protein/protein interaction (IC50 of ≤100 nM).
T26859	BMS-8	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-8 抑制PD-1/PD-L1相互作用(IC50:7.2 μM)。它能够直接与 PD-L1 结合，促使形成 PD-L1 同源二聚体，进而阻断 PD-L1 与 PD-1 的相互作用。
T3146	BMS-202 PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2	Apoptosis; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-202 (PD1-PDL1 inhibitor 2) 是一种非肽类 PD-1/PD-L 复合物抑制剂，其 IC50为 18 nM，KD 为 8 μM。它与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用，具有抗肿瘤活性。
T35396	Spartalizumab (anti-PD-1)	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Spartalizumab (anti-PD-1)是一种针对PD-1的人源IgG4抗体，抑制PD-L1和PD-L2与PD-1的结合。PDR001可与PD-1以高亲和力结合，抑制其生物活性；MW: 145.8 KD。
T6136	Canertinib PD-183805,CI-1033,卡纽替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Canertinib (CI-1033) 是有效地，不可逆的EGFR 抑制剂；抑制细胞EGFR 和ErbB2自身磷酸化的IC50值分别为7.4和9 nM。
T6932	PD168393	Apoptosis; EGFR; FGFR; IGF-1R; PDGFR; PKC; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD168393 是一种细胞渗透性的选择性 EGFR 酪氨酸激酶和 ErbB2的抑制剂。它不可逆转地失活 EGF 受体，IC50值为 0.7 nM，但对胰岛素受体、PDGFR、FGFR 和 PKC 无作用。
T39904	PD-1-IN-24
	PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor.
T12386	PD-1-IN-18	Others	Others
	PD-1-IN-18 is a PD1 inhibitor of signaling pathway, and acts as an immunomodulator.
T12377	PD-1-IN-17	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1-IN-17 是程序性细胞死亡 1 (PD-1) 的抑制剂。 PD-1-IN-17 在 100 nM 时抑制 92% 的脾细胞增殖。
T12378	PD-1-IN-20	Others	Others
	PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.
T23127	PD-161570 PD 161570	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂，IC50 为 39.9 nM，Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶，IC50 值分别为 310、240 和 44 nM。
TP1463	PD-1/PD-L1-IN 3 TFA (1629654-95-0 free base) PD-1/PD-L1-IN 3 TFA
	PD-1/PD-L1-IN 3 TFA inhibits the binding of human PD-1 to PD-Ll with an IC50 of 9 nM.
T8976	PD-089828	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-089828 是受体酪氨酸激酶 FGFR1、PDGFRβ 和 EGFR 的竞争性抑制剂，IC50分别为0.15、1.76 和 5.47 µM。它也是非受体酪氨酸激酶 c-Src 的非竞争性抑制剂，IC50 为 0.18 µM。
T2501	Canertinib dihydrochloride CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib,卡奈替尼二盐酸盐	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Canertinib dihydrochloride (PD-183805 dihydrochloride) 是一种可口服的喹唑啉盐酸盐，具有潜在的抗肿瘤和放射增敏活性，抑制细胞 EGFR 和 ErbB2自身磷酸化的 IC50值分别为 7.4 和 9 nM。
T21737L	PD-1/PD-L1 Inhibitor 3 acetate (1629654-95-0 Free base)
	PD-1/PD-L1 Inhibitor 3 acetate (1629654-95-0 Free base) 抑制人 PD-1 与 PD-L1 的结合，IC50 为 9 nM。
T12377L	PD-1-IN-17 (TFA) (1673560-66-1 free base) PD-1-IN-17 (TFA)	Others	Others
	PD-1-IN-17 TFA is a inhibitor of programmed cell death-1 (PD-1) .
T2041	PD153035 NSC 669364,SU-5271,ZM 252868,AG1517	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD153035 (NSC-669364) 是一种EGFR 抑制剂，Ki 和IC50值分别为6和25 pM。
T78269	Anti-Mouse PD-1 Antibody (RMP1-14)	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	RMP1-14 是一种 IgG1 样免疫球蛋白抗小鼠 PD-1 抗体，可阻断 PD-1/PD-L1 信号传导。
T1761	PD153035 hydrochloride ZM 252868 HCl,AG 1517,Tyrphostin AG 1517,SU 5271,PD153035 HCl,ZM 252868	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD153035 hydrochloride (ZM 252868) 是有效地EGFR 抑制剂，Ki 和IC50值分别为6和25 pM。
T22674	Co 101244 hydrochloride Co 101244盐酸盐,4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride	NMDAR	Neuroscience
	Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) 是一种含有 NR2B 的 NMDA 受体拮抗剂。
T12378L	CA-170 PD-1-IN-1	Others	Others
	PD-1-IN-1 is a programmed cell dealth-1inhibitor. PD-1-IN-1 can be used as an immune modulator.
T31424	DIBA PD022551,NSC 654077,DIBA-1,PD-22551,DIBA (Antineoplastic)
	DIBA is an ER zinc finger inhibitor that inhibits ligand-dependent and non-dependent cell growth in TAM resistant breast cancer in vitro and in vivo.
T72724	PD-1/PD-L1-IN-30
	PD-1/PD-L1-IN-30 是一种 PD-1/PD-L1结合抑制剂，IC50值为 0.018 μM。PD-1/PD-L1-IN-30 可用于癌症及其他相关疾病的研究。
T61968	PD-1/PD-L1-IN 6
	PD-1/PD-L1-IN 6 (compound A13) 是有效的PD-1/PD-L1相互作用抑制剂（IC50为 132.8 nM）。PD-1/PD-L1-IN 6 显示出显著的免疫调节活性。在 Hep3B/OS-8/hPD-L1 与 CD3 T 细胞共培养模型中，PD-1/PD-L1-IN 6显著提高干扰素 -γ 分泌，且无明显毒性作用。在 T 细胞-肿瘤共培养模型中，PD-1/PD-L1-IN 6恢复免疫应答。
T72670	PD-1/PD-L1-IN-13
	PD-1/PD-L1-IN-13 是一种有效的免疫检查点 PD-1/PD-L1抑制剂，对 PD-1/PD- L1 相互作用的 IC50值为 10.2 nM。PD-1/PD-L1-IN-13 在 Hepa1-6 同系小鼠模型中促进 CD8+T 细胞活化并延缓肿瘤生长。
T72680	PD-1/PD-L1-IN-27	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-27是一种针对PD-1/PD-L1的有效抑制剂，具有134 nM的IC50值。该化合物表现出具有低T细胞毒性的抗肿瘤活性，并能够激活CD8+T细胞以及减少T细胞耗竭。
T72691	PD-1/PD-L1-IN-28
	PD-1/PD-L1-IN-28（化合物3），一种针对PD-1/PD-L1信号通路的免疫检查点抑制剂，具IC50值为0.744 µM，展现出在肿瘤免疫治疗领域的研究潜力。
T79576	PD-1/PD-L1-IN-32	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-32（compound A56）为高效抗PD-1/PD-L1抑制剂，IC50值为2.4 nM，显示出抗癌活性。在hPD-L1 MC38人源化小鼠模型中，该化合物能显著抑制肿瘤生长，同时对小鼠未见明显毒性。
T64086	PD-1/PD-L1-IN-20
	PD-1/PD-L1-IN-20 是一种小分子的 PD-1/PD-L1蛋白-蛋白相互作用抑制剂。PD-1/PD-L1-IN-20 可阻断 PD-1/PD-L1 相互作用 (IC50: 5.29 nM)。PD-1/PD-L1-IN-20 能够用于研究癌症、传染病和自身免疫性疾病。
T63329	PD-1/PD-L1-IN-25
	PD-1/PD-L1-IN-25 是一种 PD-1/PD-L1 互作的抑制剂 (IC50: 16.17 nM)，可有效激活 PBMCs 中 T 细胞的抗肿瘤免疫。PD-1/PD-L1-IN-25 能够用于研究癌症。
T63614	PD-1/PD-L1-IN-15
	PD-1/PD-L1-IN-15 是 PD-1/PD-L1 的有效抑制剂 (IC50: 60.1 nM)，对肿瘤免疫治疗表现出研究潜力。
T72675	PD-1/PD-L1-IN-23
	PD-1/PD-L1-IN-23为一种高效的口服活性PD-1/PD-L1抑制剂，是L7酯类的前药形式。L7为苯并[c][1,2,5]恶二唑衍生物，作为PD-L1抑制剂在生物学上进行评估。PD-1/PD-L1-IN-23在同基因和PD-L1人源化小鼠的肿瘤模型中展现出显著的抗肿瘤效果。
T72721	PD-1/PD-L1-IN-29
	PD-1/PD-L1-IN-29(S4-1)，有效PD-1/PD-L1抑制剂，IC50值为6.1 nM。能够结合PD-L1，破坏PD-1/PD-L1相互作用，诱导PD-L1二聚化与内化，有助于改善其对内质网的定位并促进PD-L1进入内质网，展现出抗癌活性。
T63948	PD-1/PD-L1-IN-16
	PD-1/PD-L1-IN-16 是 PD-1/PD-L1 的有效抑制剂 (IC50: 53.2 nM)，对肿瘤免疫治疗表现出研究潜力。
T79205	PD-1/PD-L1-IN-34	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-34（化合物(1S,2S)-A25）能有效地抑制PD-1/PD-L1相互作用，其IC50值为0.029 μM，表现出对PD-L1的选择性结合亲和力，KD值为0.1554 μM。该化合物通过激活免疫微环境来抑制肿瘤生长。
T39588	Human PD-L1 inhibitor IV Human PD-L1 inhibitor IV
	Human PD-L1 inhibitor IV is a polypeptide compound that competitively inhibits the human PD-1 protein. It has a Kd value of 1.38 μM and effectively blocks the interaction between hPD-1 and hPD-L1.
T39591	Human PD-L1 inhibitor I Human PD-L1 inhibitor I
	Human PD-L1 inhibitor I is a peptide ligand that specifically inhibits the interaction between human PD-L1 and human PD-1. It exhibits a KD value of 3.39 μM, indicating its binding affinity. The presence of Human PD-L1 inhibitor I disrupts the binding between human PD-L1 and human PD-1, thereby attenuating their respective functions.
T39589	Human PD-L1 inhibitor III Human PD-L1 inhibitor III
	Human PD-L1 inhibitor III is a human PD-L1 inhibitor.
T39590	Human PD-L1 inhibitor II Human PD-L1 inhibitor II
	Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.

化合物

PD-1/PD-L1-IN-9

Cat.No: T9651

Target: PD-1/PD-L1

PD-1/PD-L1-IN-10

Cat.No: T9616

Target: PD-1/PD-L1

Cat.No: T12379

Target: Others, PD-1/PD-L1

Sintilimab (anti-PD-1)

Cat.No: T35394

Synonym: IBI308,Sintilimab (anti-PD-1)

Target: PD-1/PD-L1

Cat.No: T3655

Synonym: PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1

Target: Apoptosis, PD-1/PD-L1

Cat.No: T36899

Synonym: PD-1/PD-L1-IN-8

Target: PD-1/PD-L1

PD-1/PD-L1-IN-NP19

Cat.No: T36900

Synonym: PD-1/PD-L1-IN-NP19

Target: PD-1/PD-L1

Cat.No: T36487

Synonym: PD-1/PD-L1-IN 7,GS-4224

Target: Antiviral, HBV, PD-1/PD-L1

PROTAC PD-1/PD-L1 degrader-1

Cat.No: T40112

Synonym: PROTAC PD-1/PD-L1 degrader-1

Cat.No: T5410

Target: EGFR

BMS202 hydrochloride (1675203-84-5(free base))

Cat.No: T4696

Synonym: PD-1/PD-L1 inhibitor 2 hydrochloride

Target: PD-1/PD-L1

PD-1/PD-L1-IN 5 TFA

Cat.No: T12380

Synonym: PD-1/PD-L1-IN 5

Target: Others

Cat.No: T26859

Target: PD-1/PD-L1

Cat.No: T3146

Synonym: PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2

Target: Apoptosis, PD-1/PD-L1

Spartalizumab (anti-PD-1)

Cat.No: T35396

Target: PD-1/PD-L1

Cat.No: T6136

Synonym: PD-183805,CI-1033,卡纽替尼

Target: EGFR

Cat.No: T6932

Target: Apoptosis, EGFR, FGFR, IGF-1R, PDGFR, PKC, Autophagy

Cat.No: T39904

Cat.No: T12386

Target: Others

Cat.No: T12377

Target: PD-1/PD-L1

Cat.No: T12378

Target: Others

Cat.No: T23127

Synonym: PD 161570

Target: EGFR, FGFR, PDGFR, Src

PD-1/PD-L1-IN 3 TFA (1629654-95-0 free base)

Cat.No: TP1463

Synonym: PD-1/PD-L1-IN 3 TFA

Cat.No: T8976

Target: EGFR, FGFR, PDGFR, Src

Canertinib dihydrochloride

Cat.No: T2501

Synonym: CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib,卡奈替尼二盐酸盐

Target: EGFR

PD-1/PD-L1 Inhibitor 3 acetate (1629654-95-0 Free base)

Cat.No: T21737L

PD-1-IN-17 (TFA) (1673560-66-1 free base)

Cat.No: T12377L

Synonym: PD-1-IN-17 (TFA)

Target: Others

Cat.No: T2041

Synonym: NSC 669364,SU-5271,ZM 252868,AG1517

Target: EGFR

Anti-Mouse PD-1 Antibody (RMP1-14)

Cat.No: T78269

Target: PD-1/PD-L1

PD153035 hydrochloride

Cat.No: T1761

Synonym: ZM 252868 HCl,AG 1517,Tyrphostin AG 1517,SU 5271,PD153035 HCl,ZM 252868

Target: EGFR

Co 101244 hydrochloride

Cat.No: T22674

Synonym: Co 101244盐酸盐,4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride

Target: NMDAR

Cat.No: T12378L

Synonym: PD-1-IN-1

Target: Others

Cat.No: T31424

Synonym: PD022551,NSC 654077,DIBA-1,PD-22551,DIBA (Antineoplastic)

PD-1/PD-L1-IN-30

Cat.No: T72724

PD-1/PD-L1-IN 6

Cat.No: T61968

PD-1/PD-L1-IN-13

Cat.No: T72670

PD-1/PD-L1-IN-27

Cat.No: T72680

Target: PD-1/PD-L1

PD-1/PD-L1-IN-28

Cat.No: T72691

PD-1/PD-L1-IN-32

Cat.No: T79576

Target: PD-1/PD-L1

PD-1/PD-L1-IN-20

Cat.No: T64086

PD-1/PD-L1-IN-25

Cat.No: T63329

PD-1/PD-L1-IN-15

Cat.No: T63614

PD-1/PD-L1-IN-23

Cat.No: T72675

PD-1/PD-L1-IN-29

Cat.No: T72721

PD-1/PD-L1-IN-16

Cat.No: T63948

PD-1/PD-L1-IN-34

Cat.No: T79205

Target: PD-1/PD-L1

Human PD-L1 inhibitor IV

Cat.No: T39588

Synonym: Human PD-L1 inhibitor IV

Human PD-L1 inhibitor I

Cat.No: T39591

Synonym: Human PD-L1 inhibitor I

Human PD-L1 inhibitor III

Cat.No: T39589

Synonym: Human PD-L1 inhibitor III

Human PD-L1 inhibitor II

Cat.No: T39590

Synonym: Human PD-L1 inhibitor II

Cat. No.	Product Name	Target	Signaling Pathways
TN1051	1-Caffeoylquinic acid 金银花,1-咖啡酰奎宁酸	NF-κB	NF-κB
	1-Caffeoylquinic acid 是一种有效的NF-κB 抑制剂，对 p105 的 RH 结构域显示高结合亲和力，Ki= 0.002 μM，结合能为 1.50 Kcal/mol。它抑制PD-1/PD-L1相互作用。它具有抗氧化应激能力。
T6S0071	Fraxinellone	HIF/HIF Prolyl-Hydroxylase; STAT; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Stem Cells
	Fraxinellone 是从白鲜的根皮中分离出来的一种天然产物，是PD-L1抑制剂，可抑制HIF-1α蛋白质合成。它通过靶向 PD-L1，有用于癌症免疫的潜力。
T2763	Panaxadiol 人参二醇,20(R)-Panaxadiol	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Panaxadiol (20(R)-Panaxadiol) 是从人参根中获得，具有神经保护和抗肿瘤作用，能够抑制程序性细胞死亡配体-1(PD-L1)的表达和肿瘤增殖。

天然产物

1-Caffeoylquinic acid

Cat.No: TN1051

Synonym: 金银花,1-咖啡酰奎宁酸

Target: NF-κB

Cat.No: T6S0071

Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1

Cat.No: T2763

Synonym: 人参二醇,20(R)-Panaxadiol

Target: Others, HIF/HIF Prolyl-Hydroxylase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05395	PD-1 Protein, Mouse, Recombinant (hFc) Ly101,PD-1,programmed ce...	Mouse	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00996	PD-1 Protein, Mouse, Recombinant (His) programmed cell death 1,Pdc1,Ly	Mouse	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05079	PD-1 Protein, Human, Recombinant (mFc) PD-1,SLEB2,hSLE1,CD279,programmed...	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00897	PD-1 Protein, Human, Recombinant (His) PD1,hPD-l,hPD-1...	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04898	PD-1 Protein, Human, Recombinant (hFc) PD1,programmed cell death 1,P...	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04967	PD-1 Protein, Mouse, Recombinant (His), Biotinylated PD-1,programmed cell death 1,Ly	Mouse	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00896	PD-1 Protein, Human, Recombinant (His & hFc) PD1,hPD-l,SLEB2,programmed cell d...	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPK-00181	PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated SLEB2,PD-1,PDCD1,PD<...	Mouse	HEK293
	Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
TMPY-04343	PD-L1 Protein, Human, Recombinant (His) PDL1,B7-H,B7H1,PDCD1...	Human	HEK293
	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPY-04949	PD-L1 Protein, Human, Recombinant (His), Biotinylated PDCD1LG1,B7H1,PD	Human	HEK293
	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPK-00688	PD-1 Protein, Canine, Recombinant (aa 25-170, hFc) CD279,PDCD1,SLEB2,PD1,	Canine	HEK293
	Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
TMPY-06336	PD-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated SLEB2,hPD-1,programmed cell death 1	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05619	PD-1 Protein, Human, Recombinant (His), Biotinylated hPD-l,PD-1,SLEB2,PD1...	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05208	PD-L1 Protein, Human, Recombinant CD274 molecule,PDCD1L1,PD	Human	HEK293
	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPY-05827	PD-L2 Protein, Human, Recombinant (mFc) PDCD1L2,bA574F11.2,Btdc,...	Human	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPK-00180	PD-1 Protein, Human, Recombinant (aa 25-167, hFc & Avi), Biotinylated PD-1,PDCD1,CD279,SLEB2,<...	Human	HEK293
	Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
TMPY-04342	PD-1 Protein, Canine, Recombinant (His) programmed cell death 1	Canine	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-05260	PD-1 Protein, Cynomolgus, Recombinant (His) programmed cell death 1	Cynomolgus	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04957	PD-L2 Protein, Human, Recombinant (His), Biotinylated B7DC,Btdc,B7-DC,bA574F11.2,PDL2,p...	Human	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPY-06682	PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His) hPD-1,hSLE1,hPD-l,CD279,...	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04346	PD-L2 Protein, Human, Recombinant (His) PD-L2,B7-DC,CD273,Btdc,PDCD1L2,B7...	Human	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPY-05815	PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated programmed cell death 1	Canine	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-02512	Alpha-Synuclein Protein, Human, Recombinant PD1,α-Synuclein,PARK4,synuclein, α (non A4...	Human	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the...
TMPY-03219	VISTA Protein, Human, Recombinant (His) DD1α,V-set immunoregulatory receptor,SISP1...	Human	HEK293
	VSIR (V-Set Immunoregulatory Receptor, also known as VISTA) is a Protein Coding gene. VISTA is an immunoregulatory receptor that inhibits the T-cell response. It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. VSIR, or V-set immunoregulatory receptor, could be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ a...
TMPK-00182	PD-L1 Protein, Human, Recombinant (aa 19-238, His & Avi), Biotinylated PDL1,PD-L1B7 homolog	Human	HEK293
	B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance.
TMPK-00662	PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated PDCD1LG1,B7-H1,B7H1<...	Cynomolgus,Rhesus macaque	HEK293
	B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance.
TMPY-05282	PD-L2 Protein, Mouse, Recombinant (His), Biotinylated PD-L2,programmed cell death 1 ligand 2,B7-...	Mouse	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPJ-00638	PD-L1 Protein, Cynomolgus, Recombinant (His) B7-H,B7-H1,PDL1,PDCD...	Cynomolgus	Human Cells
	CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may in...
TMPJ-00637	PD-L1 Protein, Cynomolgus, Recombinant (hFc) B7-H,PD-L1B7 homolog 1,Programmed...	Cynomolgus	Human Cells
	CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may in...
TMPY-02352	PD-L2 Protein, Mouse, Recombinant (His) programmed cell death 1 ligand 2,Btdc,F73001	Mouse	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPY-02436	PD-L2 Protein, Mouse, Recombinant (hFc) F730015O22Rik,Btdc,PD-L2,programmed cell d...	Mouse	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPY-05238	PD-L1 Protein, Human, Recombinant (hFc), Biotinylated PDL1,B7H1,PDCD1...	Human	HEK293
	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPY-02712	Serpin B3 Protein, Human, Recombinant (His) T4-A,HsT1196,serpin peptidase inhibitor, c...	Human	Baculovirus-Insect Cells
	SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be...
TMPY-00633	PD-1 Protein, Rhesus, Recombinant (hFc) programmed cell death 1	Rhesus	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00250	PD-1 Protein, Rhesus, Recombinant (His) programmed cell death 1	Rhesus	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-03717	PD-1 Protein, Rat, Recombinant (hFc) programmed cell death 1	Rat	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-04648	PD-L1 Protein, Human, Recombinant (mFc) CD274 molecule,B7-H1,PDL1,PD<...	Human	HEK293
	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPY-06276	PD-L1 Protein, Human, Recombinant (His & Avi), Biotinylated PD-L1,PDL1,CD274 molecul...	Human	HEK293
	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPY-00676	PD-L1 Protein, Human, Recombinant (hFc) PDCD1LG1,B7-H,PDCD1<...	Human	HEK293
	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 fa...
TMPY-06281	PD-L2 Protein, Human, Recombinant (hFc & Avi), Biotinylated bA574F11.2,B7DC,B7-DC,PDCD1	Human	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPJ-00183	PD-L1 Protein, Human, Recombinant (Flag) B7-H1,Programmed Cell Death 1 Ligand 1...	Human	Human Cells
	CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may in...
TMPJ-00182	PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated B7-H1,PDCD1LG1,PD	Human	Human Cells
	CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may in...
TMPY-04341	PD-1 Protein, Rat, Recombinant (His) programmed cell death 1	Rat	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPY-00233	PD-1 Protein, Canine, Recombinant (hFc) programmed cell death 1	Canine	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
TMPK-01186	B7-H5/Gi24/VISTA Protein, Human, Recombinant (His) VSIR,B7H5,4632428N05Rik,SISP1,PP2135,Dies<...	Human	HEK293
	B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces.
TMPY-05184	VISTA Protein, Human, Recombinant (His), Biotinylated DD1alpha,VISTA,B7H5,V-set immunoregulatory receptor...	Human	HEK293
	VSIR (V-Set Immunoregulatory Receptor, also known as VISTA) is a Protein Coding gene. VISTA is an immunoregulatory receptor that inhibits the T-cell response. It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. VSIR, or V-set immunoregulatory receptor, could be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ a...
TMPY-00120	PD-L2 Protein, Human, Recombinant (hFc) Btdc,B7-DC,programmed cell death 1 ligand 2,B7DC,	Human	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPK-01185	B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc) PP2135,SISP1,VISTA,Gi24,B7H5,4632428N05Rik...	Human	HEK293
	B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces.
TMPY-05613	PD-L2 Protein, Human, Recombinant (His & Avi), Biotinylated bA574F11.2,programmed cell death 1	Human	HEK293
	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B ...
TMPY-00253	PD-1 Protein, Cynomolgus, Recombinant (hFc) programmed cell death 1	Cynomolgus	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, c...
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重组蛋白

PD-1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-05395

Species: Mouse

Expression System: HEK293

PD-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00996

Species: Mouse

Expression System: HEK293

PD-1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05079

Species: Human

Expression System: HEK293

PD-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00897

Species: Human

Expression System: HEK293

PD-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04898

Species: Human

Expression System: HEK293

PD-1 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-04967

Species: Mouse

Expression System: HEK293

PD-1 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00896

Species: Human

Expression System: HEK293

PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00181

Species: Mouse

Expression System: HEK293

PD-L1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04343

Species: Human

Expression System: HEK293

PD-L1 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04949

Species: Human

Expression System: HEK293

PD-1 Protein, Canine, Recombinant (aa 25-170, hFc)

Cat.No: TMPK-00688

Species: Canine

Expression System: HEK293

PD-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06336

Species: Human

Expression System: HEK293

PD-1 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05619

Species: Human

Expression System: HEK293

PD-L1 Protein, Human, Recombinant

Cat.No: TMPY-05208

Species: Human

Expression System: HEK293

PD-L2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05827

Species: Human

Expression System: HEK293

PD-1 Protein, Human, Recombinant (aa 25-167, hFc & Avi), Biotinylated

Cat.No: TMPK-00180

Species: Human

Expression System: HEK293

PD-1 Protein, Canine, Recombinant (His)

Cat.No: TMPY-04342

Species: Canine

Expression System: HEK293

PD-1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-05260

Species: Cynomolgus

Expression System: HEK293

PD-L2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04957

Species: Human

Expression System: HEK293

PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His)

Cat.No: TMPY-06682

Species: Human

Expression System: HEK293

PD-L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04346

Species: Human

Expression System: HEK293

PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05815

Species: Canine

Expression System: HEK293

Alpha-Synuclein Protein, Human, Recombinant

Cat.No: TMPY-02512

Species: Human

Expression System: E. coli

VISTA Protein, Human, Recombinant (His)

Cat.No: TMPY-03219

Species: Human

Expression System: HEK293

PD-L1 Protein, Human, Recombinant (aa 19-238, His & Avi), Biotinylated

Cat.No: TMPK-00182

Species: Human

Expression System: HEK293

PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated

Cat.No: TMPK-00662

Species: Cynomolgus,Rhesus macaque

Expression System: HEK293

PD-L2 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05282

Species: Mouse

Expression System: HEK293

PD-L1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00638

Species: Cynomolgus

Expression System: Human Cells

PD-L1 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-00637

Species: Cynomolgus

Expression System: Human Cells

PD-L2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02352

Species: Mouse

Expression System: HEK293

PD-L2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02436

Species: Mouse

Expression System: HEK293

PD-L1 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05238

Species: Human

Expression System: HEK293

Serpin B3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02712

Species: Human

Expression System: Baculovirus-Insect Cells

PD-1 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-00633

Species: Rhesus

Expression System: HEK293

PD-1 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-00250

Species: Rhesus

Expression System: HEK293

PD-1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03717

Species: Rat

Expression System: HEK293

PD-L1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04648

Species: Human

Expression System: HEK293

PD-L1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06276

Species: Human

Expression System: HEK293

PD-L1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00676

Species: Human

Expression System: HEK293

PD-L2 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06281

Species: Human

Expression System: HEK293

PD-L1 Protein, Human, Recombinant (Flag)

Cat.No: TMPJ-00183

Species: Human

Expression System: Human Cells

PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPJ-00182

Species: Human

Expression System: Human Cells

PD-1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04341

Species: Rat

Expression System: HEK293

PD-1 Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-00233

Species: Canine

Expression System: HEK293

B7-H5/Gi24/VISTA Protein, Human, Recombinant (His)

Cat.No: TMPK-01186

Species: Human

Expression System: HEK293

VISTA Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05184

Species: Human

Expression System: HEK293

PD-L2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00120

Species: Human

Expression System: HEK293

B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01185

Species: Human

Expression System: HEK293

PD-L2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05613

Species: Human

Expression System: HEK293

PD-1 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-00253

Species: Cynomolgus

Expression System: HEK293

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