Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes. Additionally, PD 144418 oxalate demonstrates potential antipsychotic activity.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 987 | 现货 | ||
2 mg | ¥ 1,460 | 现货 | ||
5 mg | ¥ 2,430 | 现货 | ||
10 mg | ¥ 3,660 | 现货 | ||
25 mg | ¥ 5,890 | 现货 | ||
50 mg | ¥ 7,830 | 现货 | ||
100 mg | ¥ 10,700 | 现货 | ||
500 mg | ¥ 21,600 | 现货 |
产品描述 | PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes. Additionally, PD 144418 oxalate demonstrates potential antipsychotic activity. |
靶点活性 | σ2 receptor:1377 nM (Ki), σ1 receptor:0.08 nM (Ki) |
体外活性 | In vitro, PD 144418 reverses the N-methyl-D-aspartate (NMDA)-induced increase in cyclic GMP (cGMP) in rat cerebellar slices without affecting the basal levels, suggesting that σ1 sites may be important in the regulation of glutamine-induced actions. PD 144418 potentiates the decrease in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region, but by itself has no effect in 5-HT and dopamine (DA) synthesis [1] . |
体内活性 | PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED 50 values of 7.0 mg/kg i.p. [1] . Animal Model: Male CD-1 mice induced with Mescaline [1] Dosage: 10 mg/kg Administration: Intraperitoneal injection; once Result: Antagonized mescaline-induced scratching at doses that did not alter spontaneous motor activity. |
分子量 | 372.42 |
分子式 | C20H24N2O5 |
CAS No. | 1794760-28-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (26.85 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6851 mL | 13.4257 mL | 26.8514 mL | 67.1285 mL |
5 mM | 0.537 mL | 2.6851 mL | 5.3703 mL | 13.4257 mL | |
10 mM | 0.2685 mL | 1.3426 mL | 2.6851 mL | 6.7129 mL | |
20 mM | 0.1343 mL | 0.6713 mL | 1.3426 mL | 3.3564 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PD 144418 oxalate 1794760-28-3 GPCR/G Protein Sigma receptor PD 144418 Oxalate PD-144418 Oxalate PD144418 Oxalate Inhibitor inhibitor inhibit