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PD-1 Protein, Human, Recombinant (CHO, hFc)

产品编号 TMPS-00113

PD-1 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q15116.

PD-1 Protein, Human, Recombinant (CHO, hFc)

产品编号 TMPS-00113

PD-1 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q15116.

规格	价格	库存	数量
50 μg	¥ 1,720	5日内发货
1 mg	¥ 17,200	5日内发货

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产品信息

生物活性	Assay #1: Immobilized PD-L1, hFc, Human (Cat. No.: Z03371) at 1.0 μg/ml (100 μl/well) can bind biotinylated PD-1, hFc, Human. Assay #2: Immobilized PD-L1, His, Human(Cat. No.: Z03425) at 2.0 μg/ml (100 µl/well) can bind PD-1, hFc, Human.
产品描述	PD-1 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q15116.
种属	Human
表达系统	CHO Cells
标签	hFc
蛋白编号	Q15116
别名	Programmed cell death 1,PDCD1,PD-1,CD279
蛋白构建	Leu25-Gln167
蛋白纯度	> 98% as determined by SDS-PAGE
分子量	60~65 kDa (Reducing conditions)
内毒素	< 0.2 EU/μg of protein as determined by the LAL method.
缓冲液	Lyophilized from a 0.2 μm filtered solution in PBS.
复溶方法	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279) or PDCD1, is a protein that in humans is encoded by the PDCD1 gene. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells.PD-1 binds two ligands, PD-L1 and PD-L2. PD-1 and its ligands play an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells)