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Anti-PD-1 Antibody (9O437)
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产品编号 TMAH-00865
别名 SLEB2, PDCD1, PD-1, PD1, CD279
Anti-PD-1 Antibody (9O437) 是一种抗体，靶向 PD-1。Anti-PD-1 Antibody (9O437) 可用于 ELISA, WB, IHC。
Anti-PD-1 Antibody (9O437)
Anti-PD-1 Antibody (9O437)
还可以产品编号 TMAH-00865 别名 SLEB2, PDCD1, PD-1, PD1, CD279
Anti-PD-1 Antibody (9O437) 是一种抗体，靶向 PD-1。Anti-PD-1 Antibody (9O437) 可用于 ELISA, WB, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-PD-1 Antibody (9O437) is an antibody targeting PD-1. Anti-PD-1 Antibody (9O437) can be used in ELISA, WB, IHC. |
| 别名 | SLEB2, PDCD1, PD-1, PD1, CD279 |
| Ig Type | Rabbit IgG |
| 克隆号 | 9O437 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in: MCF-7 whole cell lysate -All lanes: PD1 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 32 KDa -Observed band size: 32 kDa 2. IHC image of TMAH-00865 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, WB, IHC |
| 推荐剂量 | WB:1:500-1:5000; IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human PD1 |
| 抗原种属 | Human |
| 基因ID | 5133 |
| Uniprot ID | |
| 研究领域 | Cancer, Cell biology, Immunology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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