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Anti-PD-1 Antibody-PE (5M150)
还可以产品编号 TMAY-00718P
Anti-PD-1 Antibody-PE (5M150) 是一种 PE-conjugated Mouse 抗体，靶向 PD-1。Anti-PD-1 Antibody-PE (5M150) 可用于 FCM。
Anti-PD-1 Antibody-PE (5M150)
Anti-PD-1 Antibody-PE (5M150)
还可以产品编号 TMAY-00718P
Anti-PD-1 Antibody-PE (5M150) 是一种 PE-conjugated Mouse 抗体，靶向 PD-1。Anti-PD-1 Antibody-PE (5M150) 可用于 FCM。
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产品介绍
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抗原信息
| 产品描述 | Anti-PD-1 Antibody-PE (5M150) is a PE-conjugated Mouse antibody targeting PD-1. Anti-PD-1 Antibody-PE (5M150) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5M150 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human PD-1 (CD279) expression on PHA-activated human whole blood Lymphocytes. Cells were stained with PE-conjugated anti-Human PD-1 (CD279). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable Lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells, and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Blockade: Blocking AntibodiImmune Checkpoint Blockade: PD1 / PDCD1 / CD2Immune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyPD1 / PDCD1 / CD279 Immune CheckpointPD1 / PDCD1 / CD279 Immune Checkpoint AntibodPD1 / PDCD1 / CD279 Immune Checkpoint ProteinTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC/PerCP/FITC |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human PD1/PDCD1/CD279 Protein (TMPY-00897) |
| 抗原种属 | Human |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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