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Alpha-Synuclein Protein,Human,Recombinant (H50Q)

产品编号 TMPY-06318

别名: Human α-Synuclein Protein (H50Q), synuclein, alpha (non A4 component of amyloid precursor), PARK1, PARK4, NACP, synuclein, α (non A4 component of amyloid precursor), PD1

Alpha-Synuclein Protein,Human,Recombinant (H50Q) is expressed in E. coli expression system. The predicted molecular weight is 14.45 kDa and the accession number is P37840-1.

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Alpha-Synuclein Protein,Human,Recombinant (H50Q)

规格	价格/CNY		货期	数量
100 μg	￥ 1,890		5日内发货
1 mg	￥ 12,300		5日内发货

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生物活性	Testing in progress
产品描述	Alpha-Synuclein Protein,Human,Recombinant (H50Q) is expressed in E. coli expression system. The predicted molecular weight is 14.45 kDa and the accession number is P37840-1.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	P37840-1
别名	Human α-Synuclein Protein (H50Q), synuclein, alpha (non A4 component of amyloid precursor), PARK1, PARK4, NACP, synuclein, α (non A4 component of amyloid precursor), PD1
蛋白构建	Human SNCA (P37840-1) (H50Q, Met1-Ala140)
蛋白纯度	≥ 90 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	14.45 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS 2 mM TCEP, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). Besides, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.

参考文献

1. Arima K, et al. (1998) Immunoelectron-microscopic demonstration of NACP / alpha-synuclein-epitopes onthe filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies. Brain Res. 808 (1): 93-100. 2. Arima K, et al. (1998) NACP / alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol. 96 (5): 439-44. 3. Lee HJ, et al. (2001) Membrane-bound alpha-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form. The Journal of Biological Chemistry. 277: 671-8.

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Keywords

Alpha-Synuclein Protein,Human,Recombinant (H50Q) PARK-4 non A4 component of amyloid precursor PARK 1 PARK-1 PARK 4 Human α-Synuclein Protein (H50Q) PD-1 PD 1 synuclein, alpha (non A4 component of amyloid precursor) PARK1 synuclein, alpha PARK4 NACP synuclein, α (non A4 component of amyloid precursor) PD1 recombinant recombinant-proteins proteins protein

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