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PD-L1 Protein, Human, Recombinant

PD-L1 Protein, Human, Recombinant

产品编号 TMPY-05208
别名: CD274 molecule, PDCD1L1, PD-L1, PDL1, PDCD1LG1, B7H1, B7-H, B7-H1

PD-L1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is Q9NZQ7-1.

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PD-L1 Protein, Human, Recombinant
规格 价格/CNY 货期 数量
100 μg ¥ 4,470 现货
200 μg ¥ 7,630 5日内发货
500 μg ¥ 15,450 5日内发货
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产品目录号及名称: PD-L1 Protein, Human, Recombinant (TMPY-05208)
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生物活性 Testing in progress
产品描述 PD-L1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is Q9NZQ7-1.
种属 Human
表达系统 HEK293 Cells
标签 Tag Free
蛋白编号 Q9NZQ7-1
别名 CD274 molecule, PDCD1L1, PD-L1, PDL1, PDCD1LG1, B7H1, B7-H, B7-H1
蛋白构建 Human CD274 (NP_054862.1) (Met1-Arg238)
蛋白纯度 ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

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分子量 25.2 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Blockade: Blocking AntibodiImmune Checkpoint Blockade: PD-L1 / B7-H1 / CImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyPD-L1 / B7-H1 / CD274 Immune Checkpoint ProteTargeted Therapy

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Keywords

PD-L1 Protein, Human, Recombinant CD274 molecule PDCD1L1 PD-L1 PDL1 PDL 1 PDCD1LG1 B7H1 B7-H B7-H1 PDL-1 recombinant recombinant-proteins proteins protein

 

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