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Anti-PD-1 Antibody (5R506)
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还可以产品编号 TMAH-00863
别名 PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H
Anti-PD-1 Antibody (5R506) 是一种 Mouse 抗体，靶向 PD-1。Anti-PD-1 Antibody (5R506) 可用于 ELISA,WB。
Anti-PD-1 Antibody (5R506)
Anti-PD-1 Antibody (5R506)
一键复制产品信息 还可以产品编号 TMAH-00863 别名 PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H
Anti-PD-1 Antibody (5R506) 是一种 Mouse 抗体，靶向 PD-1。Anti-PD-1 Antibody (5R506) 可用于 ELISA,WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-PD-1 Antibody (5R506) is a Mouse antibody targeting PD-1. Anti-PD-1 Antibody (5R506) can be used in ELISA,WB. |
| 别名 | PD-L1B7 homolog 1, PD-L1, PDL1, PDCD1LG1, PDCD1L1, CD274, B7-H1, B7H1, B7-H |
| Ig Type | IgG1 |
| 克隆号 | 5R506 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: 5μg 293 whole cell lysate transfected with PD-1, 25ng recombinant protein from E.coli, 25ng recombinant protein from Mammalian cell PD-1 antibody at 1:1000 -Secondary: Goat polyclonal to mouse IgG at 1/50000 dilution -Predicted band size: 72, 36 KDa -Observed band size: 72, 36 KDa -Exposure time：5min |
| 应用 | ELISAWB |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Protein G purified |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 纯度 | >95% |
| 研究背景 | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human Programmed cell death Protein 1 Protein (21-170AA) |
| 抗原种属 | Human |
| 基因名称 | PDCD1 |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Immunology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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