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Anti-PD-1 Antibody (2U287)
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产品编号 TMAH-00864
别名 SLEB2, PDCD1, PD-1, PD1, CD279
Anti-PD-1 Antibody (2U287) 是一种抗体，靶向 PD-1。Anti-PD-1 Antibody (2U287) 可用于 ELISA。
Anti-PD-1 Antibody (2U287)
Anti-PD-1 Antibody (2U287)
还可以产品编号 TMAH-00864 别名 SLEB2, PDCD1, PD-1, PD1, CD279
Anti-PD-1 Antibody (2U287) 是一种抗体，靶向 PD-1。Anti-PD-1 Antibody (2U287) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-PD-1 Antibody (2U287) is an antibody targeting PD-1. Anti-PD-1 Antibody (2U287) can be used in ELISA. |
| 别名 | SLEB2, PDCD1, PD-1, PD1, CD279 |
| Ig Type | Human IgG4 |
| 克隆号 | 2U287 |
| 交叉反应 | Human |
| 验证活性 | The Binding Activity of PD-1 with anti-PD-1 antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human PD-1 at 2 μg/mL can bind Anti-PD-1 recombinant antibody, the EC50 is 1.960-3.961 ng/mL. |
| 应用 | ELISA |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human PD-1 Protein |
| 抗原种属 | Human |
| 基因ID | 5133 |
| Uniprot ID | |
| 研究领域 | Immunology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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