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Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945)

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产品编号 TMAY-01628

别名 Zn-SMase, sphingomyelin phosphodiesterase 1, A-SMase, aSMase, ASM

Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) 是一种 Mouse 抗体，靶向 Acid sphingomyelinase/SMPD1。Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) 可用于 ELISA。

Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945)

Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945)

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产品编号 TMAY-01628 别名 Zn-SMase, sphingomyelin phosphodiesterase 1, A-SMase, aSMase, ASM

Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) 是一种 Mouse 抗体，靶向 Acid sphingomyelinase/SMPD1。Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 1,694
5日内发货
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产品介绍

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产品描述
Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) is a Mouse antibody targeting Acid sphingomyelinase/SMPD1. Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) can be used in ELISA.
别名Zn-SMase, sphingomyelin phosphodiesterase 1, A-SMase, aSMase, ASM
Ig Type
Mouse IgG1
克隆号
9W945
交叉反应
Human
特异性
Human Acid sphingomyelinase/SMPD1
应用ELISA
推荐剂量
ELISA: 1:1000-1:2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SMPD1 (rh SMPD1; TMPY-01159; NP_000534.3; Met1-Pro628). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monomeric lysosomal enzyme that converts sphingomyelin (a plasma membrane lipid ) into ceramide through the removal of phosphorylcholine. This generates second messenger components that participate in signal transduction. Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPA) and type B (NPB), also known as Niemann-Pick disease classical infantile form and Niemann-Pick disease visceral form. Niemann-Pick disease is a clinically and genetically heterogeneous recessive disorder. NPB has little if any neurologic involvement and patients may survive into adulthood.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human SMPD1 Protein (TMPY-01159)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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