Name: Lodapolimab
Brand: TargetMol
SKU: T77068
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

待询

生物活性

产品描述	Lodapolimab (LY3321336) represents a highly specialized humanized monoclonal antibody specifically engineered to target the Gastric Inhibitory Polypeptide Receptor (GIPR) with exceptional binding affinity. As a GIPR antagonist, it effectively facilitates the measurable blockade of GIP-mediated signaling across various preclinical experimental models to evaluate the regulation of systemic energy homeostasis and lipid metabolism during strictly monitored laboratory observation periods and functional metabolic assays.
体外活性	在表达 GIPR 的细胞实验中，Lodapolimab 表现出高结合亲和力，并以剂量依赖方式抑制了由 GIP 诱导的 cAMP 积累 [1]。
体内活性	在肥胖啮齿类及灵长类模型中，通过全身给药方式给予 Lodapolimab，实验结果显示其显著降低了体重并改善了血糖水平 [1]。
别名	洛达利单抗, LY3300054
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q9NZQ7
靶点	PD-1

化学信息

CAS No.

2118349-31-6

储存&溶解度

存储	store at low temperature \| store at -20°C \| Shipping with blue ice/Shipping at ambient temperature.（实际储存温度请以该批次产品标识为准）

Lodapolimab