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PD-L1 Protein, Human, Recombinant (Flag)

PD-L1 Protein, Human, Recombinant (Flag)

产品编号 TMPJ-00183
别名: B7-H1, Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1L1, B7 Homolog 1, PDCD1LG1, PDL1, B7H1, CD274, PDCD1 Ligand 1, Programmed Death Ligand 1

PD-L1 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 35-40 KDa and the accession number is Q9NZQ7.

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PD-L1 Protein, Human, Recombinant (Flag)
规格 价格/CNY 货期 数量
10 μg ¥ 500 5日内发货
50 μg ¥ 1,170 5日内发货
500 μg ¥ 8,860 5日内发货
1 mg ¥ 12,600 5日内发货
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产品目录号及名称: PD-L1 Protein, Human, Recombinant (Flag) (TMPJ-00183)
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生物活性
技术参数
产品性质
生物活性 1. Loaded Human PD-1-Fc on Protein A Biosensor, can bind Human PD-L1-Flag with an affinity constant of 0.19 uM as determined in BLI assay. (Regularly tested) 2. Immobilized Human PD-L1-Flag at 2μg/ml (100 μl/well)can bind Anti-Human PDL1 mAb-Fc. The ED50 of Anti-Human PDL1 mAb-Fc is 14.68 ng/ml. (Regularly tested)
产品描述 PD-L1 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 35-40 KDa and the accession number is Q9NZQ7.
种属 Human
表达系统 HEK293 Cells
标签 C-Flag
蛋白编号 Q9NZQ7
别名 B7-H1, Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1L1, B7 Homolog 1, PDCD1LG1, PDL1, B7H1, CD274, PDCD1 Ligand 1, Programmed Death Ligand 1
氨基酸序列 Phe19-Thr239
蛋白构建 Phe19-Thr239
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 35-40 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

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Keywords

PD-L1 Protein, Human, Recombinant (Flag) PDL 1 B7-H1 CD 274 Programmed Cell Death 1 Ligand 1 PDL-1 PD-L1 PDCD1L1 B7 Homolog 1 PDCD1LG1 CD-274 PDL1 B7H1 CD274 PDCD1 Ligand 1 Programmed Death Ligand 1 recombinant recombinant-proteins proteins protein

 

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