c11

Mito-apocynin (C11)是一种线粒体靶向抗氧化剂，通过靶向和中和细胞呼吸过程中产生的活性氧（ROS）发挥作用。三苯基溴化鏻已被发现能有效预防线粒体功能障碍，线粒体功能障碍是衰老过程和各种疾病的主要原因。它具有抗炎、抗凋亡和抗氧化活性。

C-11 is a tubulin inhibitor and acts as an ADC cytotoxin with cytotoxicity for carcinoma cell lines.

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR).References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018). STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR). References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018).

LysoPalloT-NH-amide-C3-ph-m-O-C11 是一种GPR174激动剂，其EC50为34 nM。

IRES-C11是针对c-MYC基因内部核糖体进入位点(IRES)的特异性翻译抑制剂。IRES-C11通过阻断异源核糖核蛋白A1（一种对c-MYC IRES活性必需的跨作用因子）与其相应IRES之间的相互作用，从而发挥作用。值得注意的是，IRES-C11不抑制BAG-1、XIAP和p53的IRES活性。

Thalidomide-5-O-C11-NH2 hydrochloride是一款基于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物通过linker与靶向蛋白配体结合，用于构建PROTAC分子，如THAL-SNS-032。

Thalidomide-4-O-C11-NH2 hydrochloride是Thalidomide衍生的cereblon配体，能够募集CRBN蛋白。该化合物能够利用linker与目标蛋白配体结合，进而形成PROTAC分子，如THAL-SNS-032。

Pomalidomide-C11-NH2 hydrochloride 是一款以 Pomalidomide 为基础的 E3 泛素连接酶 cereblon (CRBN) 配体，主要应用于募集 cereblon 蛋白。该化合物能够借助 linker 结构与蛋白质配体相连，从而构建 PROTAC 分子。

Pomalidomide-5-C11-NH2 hydrochloride 是一款基于 Pomalidomide 的 cereblon (CRBN) E3 泛素连接酶配体，能够招募 cereblon 蛋白。通过 linker 结构，该化合物可用于构建 PROTAC，实现其与蛋白质配体的连接。

JHU-75528 C-11 can be used as a Radiotracer for PET Imaging of CB1 Cannabinoid Receptors.

Levetimide C-11 is a radiotracer.

(S)-Desmethyl-NNC112 ((+)-Desmethyl-NNC112) 是一种选择性 PET 放射性配体，可与 D-多巴胺受体结合。

BFC1108 可靶向 Bcl-2 并将其转化为促凋亡蛋白，抑制Bcl-2高表达的三阴性乳腺癌异种移植物的生长，抑制乳腺癌肺转移，促使表达 Bcl-2 的癌症细胞凋亡。

NSC117079是一种新型的的PHLPP1 2（Pleckstrin homology domain and leucine rich repeat protein phosphatase）抑制剂，在神经元中能够激活神经元AKT并改善staurosporine诱导的细胞死亡。

EC1169 is a targeted tubulysin conjugate that utilizes EC1167 as its linker. This compound shows promise in the treatment of recurrent metastatic, castration-resistant prostate cancer (MCRPC)[1].

AC1115是一种针对SARS-CoV-2 Mpro和宿主溶酶体半胱氨酸蛋白酶cathepsin L (CTSL)的高效、选择性的新一代抗病毒化合物，具有高度的抗病毒活性。

HDAC11-IN-1 (Compound 14-NC6OH) 是一种选择性HDAC11的大环抑制剂，其Ki值为40 nM。HDAC11-IN-1 展示出优异的细胞穿透能力，并抑制YAP1和SOX2的表达。

HDAC11-IN-2 (compound B6) 是一种针对组蛋白去乙酰化酶 11 (Histone Deacetylase 11, HDAC11) 的高度选择性抑制剂。其抑制HDAC11和HDAC8的IC50值分别为51.1 ×10^-3μM和5 μM。HDAC11-IN-2 能抑制新生脂肪生成 (DNL) 并促进脂肪酸氧化，从而减轻MASLD小鼠的肝脏脂质积累和病理症状。通过抑制HDAC11，该化合物增强AMPKα1在Thr172位点的磷酸化，从而调节肝脏的新生脂肪生成和脂肪酸氧化。

ABC1183是一种抑制GSK3α， GSK3β和CDK9的新型二氨基噻唑。ABC1183通过诱导G2 M 阻滞和改变GSK3、糖原合成酶、β-catenin 磷酸化和MCL1表达降低细胞存活率来抑制多种癌细胞株的生长，并具有口服活性。

MCC1189 is a first-in-class MFS efflux pump CaMdr1p inhibitor.

NSC114792 is a selective JAK3 inhibitor.

NC1153 is a blocker of IL-2-induced activation of JAK3 and its downstream substrates STAT5a b. It promotes long-term allograft survival and sparing the recipient from multiple toxicities.

Histone H3 (116-136), C116-136 is a peptide consisting of amino acids 116 to 136, which spans the C-terminus of histone H3.

NSC114126 is a highly effective and orally bioavailable inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR-TK). This compound exhibits robust antiproliferative properties, making it a promising candidate for further investigation in the field of cancer research [1].