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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-CDC2 Monoclonal Antibody (4L423)

Synonyms: P34CDC2, MGC111195, DKFZp686L20222, CDK1, CDC28A, CDC2
货号 TMAT-0464 一键复制产品信息
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Anti-CDC2 Monoclonal Antibody (4L423) 是一种 Mouse 抗体，靶向 CDC2。Anti-CDC2 Monoclonal Antibody (4L423) 可用于 WB,IHC。

Anti-CDC2 Monoclonal Antibody (4L423)

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Rating icon 还可以
货号 TMAT-0464

别名 P34CDC2, MGC111195, DKFZp686L20222, CDK1, CDC28A, CDC2

Anti-CDC2 Monoclonal Antibody (4L423) 是一种 Mouse 抗体，靶向 CDC2。Anti-CDC2 Monoclonal Antibody (4L423) 可用于 WB,IHC。

Anti-CDC2 Monoclonal Antibody (4L423)
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产品介绍

生物活性
产品描述
Anti-CDC2 Monoclonal Antibody (4L423) is a Mouse antibody targeting CDC2. Anti-CDC2 Monoclonal Antibody (4L423) can be used in WB,IHC.
别名
P34CDC2, MGC111195, DKFZp686L20222, CDK1, CDC28A, CDC2
Ig Type
IgG1
克隆号
4L423
反应种属
Human
应用WBIHC
推荐剂量
WB: 1/500-1/2000; IHC: 1/200-1/1000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液Ascitic fluid containing 0.03% sodium azide
浓度1 mg/ml
研究背景The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of CDC2 expressed in E. Coli.
抗原种属
Human
基因名称
CDK1
基因ID
983
蛋白名称
Cyclin-dependent kinase 1
Uniprot ID
P06493
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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