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Anti-BMP-4 Antibody (1Y856)
还可以产品编号 TMAY-01026
Anti-BMP-4 Antibody (1Y856) 是一种 Mouse 抗体，靶向 BMP-4。Anti-BMP-4 Antibody (1Y856) 可用于 ELISA。
Anti-BMP-4 Antibody (1Y856)
Anti-BMP-4 Antibody (1Y856)
还可以产品编号 TMAY-01026
Anti-BMP-4 Antibody (1Y856) 是一种 Mouse 抗体，靶向 BMP-4。Anti-BMP-4 Antibody (1Y856) 可用于 ELISA。
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抗原信息
| 产品描述 | Anti-BMP-4 Antibody (1Y856) is a Mouse antibody targeting BMP-4. Anti-BMP-4 Antibody (1Y856) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 1Y856 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BMP4 (rh BMP4; TMPY-06842; P12644; Ser293-Arg408). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human BMP4 Protein (TMPY-06842) |
| 抗原种属 | Human |
| 研究领域 | Early Mesodermal Lineage Markers, Cardiac Stem Cell Markers |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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