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Anti-BMP-4 Antibody (8O817)
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产品编号 TMAY-01024
别名 ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B
Anti-BMP-4 Antibody (8O817) 是一种 Mouse 抗体，靶向 BMP-4。Anti-BMP-4 Antibody (8O817) 可用于 FCM,ICC/IF。
Anti-BMP-4 Antibody (8O817)
Anti-BMP-4 Antibody (8O817)
还可以产品编号 TMAY-01024 别名 ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B
Anti-BMP-4 Antibody (8O817) 是一种 Mouse 抗体，靶向 BMP-4。Anti-BMP-4 Antibody (8O817) 可用于 FCM,ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,689 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-BMP-4 Antibody (8O817) is a Mouse antibody targeting BMP-4. Anti-BMP-4 Antibody (8O817) can be used in FCM,ICC/IF. |
| 别名 | ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B |
| Ig Type | Mouse IgM |
| 克隆号 | 8O817 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunofluorescence staining of Human BMP4 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Mouse anti-Human BMP4 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm. 2. Flow cytometric analysis of Human BMP4 on HeLa cells. Cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human BMP4, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | |
| 推荐剂量 | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BMP-4. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human BMP-4 protein |
| 抗原种属 | Human |
| 研究领域 | Early Mesodermal Lineage Markers, Cardiac Stem Cell Markers |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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