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BMP-4 Protein, Human, Recombinant (E399D)

Synonyms: ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B
货号 TMPY-06842 一键复制产品信息 纯度: 95.9%
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BMP-4 Protein, Human, Recombinant (E399D) is expressed in E. coli expression system. The predicted molecular weight is 13.25 kDa and the accession number is P12644.

BMP-4 Protein, Human, Recombinant (E399D)

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纯度: 95.9%

货号 TMPY-06842

别名 ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B

BMP-4 Protein, Human, Recombinant (E399D) is expressed in E. coli expression system. The predicted molecular weight is 13.25 kDa and the accession number is P12644.

BMP-4 Protein, Human, Recombinant (E399D)
其他形式的 “BMP-4 Protein, Human, Recombinant (E399D)”:
BMP-4 Protein, Bovine, Recombinant (GST)
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规格价格库存数量
5 μg
¥ 692
现货
10 μg
¥ 1,160
现货
20 μg
¥ 1,950
3日内发货
50 μg
¥ 3,290
现货
100 μg
¥ 4,920
5日内发货
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选择批次:
纯度: ≥ 95 % as determined by SDS-PAGE.
资源下载: COA重组蛋白用户指南

产品介绍

生物活性
产品描述
BMP-4 Protein, Human, Recombinant (E399D) is expressed in E. coli expression system. The predicted molecular weight is 13.25 kDa and the accession number is P12644.
生物活性
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.08-0.4ug/mL.
BMP-4 Protein, Human, Recombinant (E399D)
研究背景
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.
种属
Human
表达系统
E. coli
标签Tag Free
蛋白编号P12644
蛋白构建A DNA sequence encoding the human BMP4 (P12644) (Ser293-Arg408, E399D) was expressed. Predicted N terminal: Met
蛋白纯度
≥ 95% as determined by SDS-PAGE.
BMP-4 Protein, Human, Recombinant (E399D)
蛋白性状Lyophilized powder
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing 30% Acetonitrile, 1/1000 TFA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法Reconstituted with 4 mM HCl to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
别名ZYME, OFC11, MCOPS6, bone morphogenetic protein 4, BMP2B1, BMP2B
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量13.25 kDa (predicted)
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

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剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

OFC-11OFC 11MCOPS-6MCOPS 6
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