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Anti-DSG-2/Desmoglein-2 Antibody (5U33)
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产品编号 TMAC-01142
别名 MGC117037, MGC117036, HDGC, DSG2, Desmoglein-2, CMD1BB, CDHF5, ARVC10
Anti-DSG-2/Desmoglein-2 Antibody (5U33) 是一种 Rabbit 抗体，靶向 DSG-2/Desmoglein-2。Anti-DSG-2/Desmoglein-2 Antibody (5U33) 可用于 WB,IHC,FCM。
Anti-DSG-2/Desmoglein-2 Antibody (5U33)
Anti-DSG-2/Desmoglein-2 Antibody (5U33)
还可以产品编号 TMAC-01142 别名 MGC117037, MGC117036, HDGC, DSG2, Desmoglein-2, CMD1BB, CDHF5, ARVC10
Anti-DSG-2/Desmoglein-2 Antibody (5U33) 是一种 Rabbit 抗体，靶向 DSG-2/Desmoglein-2。Anti-DSG-2/Desmoglein-2 Antibody (5U33) 可用于 WB,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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生物活性
偶联与修饰
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化学信息
| 产品描述 | Anti-DSG-2/Desmoglein-2 Antibody (5U33) is a Rabbit antibody targeting DSG-2/Desmoglein-2. Anti-DSG-2/Desmoglein-2 Antibody (5U33) can be used in WB,IHC,FCM. |
| 别名 | MGC117037, MGC117036, HDGC, DSG2, Desmoglein-2, CMD1BB, CDHF5, ARVC10 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of Desmoglein 2 on A431 cell using anti-Desmoglein 2 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded rat heart tissue using anti-Desmoglein 2 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Desmoglein 2 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-Desmoglein 2 antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-Desmoglein 2 antibody. Counter stained with hematoxylin. 6. Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue using anti-Desmoglein 2 antibody. Counter stained with hematoxylin. 7. Flow cytometric analysis of A431 cells with Desmoglein 2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000; IHC: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Pemphigus is an autoimmune disease of skin adhesion associated with auto-antibodies against a number of keratinocyte antigens, such as the adhesion molecules desmoglein (dsg) 1 and 3 and acetylcholine receptors. Desmogleins, Type I membrane proteins, are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. Desmogleins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or un-usual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively. Several carcinoma cell lines constantly express dsg2 and dsg3 mRNA, whereas cultured normal human keratinocytes always express dsg1 and dsg3 mRNA, with or without dsg2 mRNA. This expression pattern indicates that desmoglein isoforms exhibit abnormal expression and may be related to tumor cell kinetics, such as cell invasion and metastasis. dsg2 is the fundamental dsg common to all desmosome-possessing tissues and is the largest desmoglein in the family. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 150 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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