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Anti-FIS1 Antibody (5I637) 是一种 Rabbit 抗体,靶向 FIS1。Anti-FIS1 Antibody (5I637) 可用于 WB,ICC,IF,IHC。
Anti-FIS1 Antibody (5I637) 是一种 Rabbit 抗体,靶向 FIS1。Anti-FIS1 Antibody (5I637) 可用于 WB,ICC,IF,IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,490 | 5日内发货 | |
100 μL | ¥ 2,495 | 5日内发货 |
产品描述 | Anti-FIS1 Antibody (5I637) is a Rabbit antibody targeting FIS1. Anti-FIS1 Antibody (5I637) can be used in WB,ICC,IF,IHC. |
别名 | TTC11, TPR Repeat Protein 11, Tetratricopeptide Repeat Protein 11, Mitochondrial Fission 1 Protein, hFis1, FIS1 Homolog, FIS1, CGI-135 |
Ig Type | IgG |
交叉反应 | Human |
验证活性 | 1. Western blot analysis of TTC11 on SK-Br-3 cell using anti-TTC11 antibody at 1/2,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-TTC11 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human small intestine tissue using anti-TTC11 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-TTC11 antibody. Counter stained with hematoxylin. 5. ICC staining TTC11 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining TTC11 in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining TTC11 in SK-Br-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
应用 | |
推荐剂量 | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | Recombinant Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | Fis1 localizes to the outer mitochondrial membrane and, along with dynamin-related protein (Drp1), participates in mitochondrial fission. Fission and fusion mechanisms regulate mitochondrial morphology within the cell. Fission frequency is determined by the level of Fis1 molecules at the mitochondrial surface. Fis1 contains a C-terminal domain, which is required for mitochondrial localization, and an N-terminal domain, which is necessary for mitochondrial fission. Fragmentation of the mitochondrial network by Fis1 leads to cytochrome c release and apoptosis. The mitochondrial fission mechanisms may be involved in positively and negatively regulating apoptosis. |
偶联 | Unconjugated |
Uniprot ID |
分子量 | Theoretical: 17 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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