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Anti-IGF2/IGF-II Antibody (1H183)
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产品编号 TMAY-03053
别名 胰岛素样生长因子, PP9974, insulin-like growth factor 2, IGF-II, C11orf43
Anti-IGF2/IGF-II Antibody (1H183) 是一种 Rabbit 抗体，靶向 IGF2/IGF-II。Anti-IGF2/IGF-II Antibody (1H183) 可用于 ELISA。
Anti-IGF2/IGF-II Antibody (1H183)
331 Anti-IGF2/IGF-II Antibody (1H183)
还可以产品编号 TMAY-03053 别名 胰岛素样生长因子, PP9974, insulin-like growth factor 2, IGF-II, C11orf43
Anti-IGF2/IGF-II Antibody (1H183) 是一种 Rabbit 抗体，靶向 IGF2/IGF-II。Anti-IGF2/IGF-II Antibody (1H183) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,294 | 5日内发货 |
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产品介绍
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抗原信息
| 产品描述 | Anti-IGF2/IGF-II Antibody (1H183) is a Rabbit antibody targeting IGF2/IGF-II. Anti-IGF2/IGF-II Antibody (1H183) can be used in ELISA. |
| 别名 | 胰岛素样生长因子, PP9974, insulin-like growth factor 2, IGF-II, C11orf43 |
| Ig Type | Rabbit IgG |
| 克隆号 | 1H183 |
| 交叉反应 | Mouse |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IGF-2/IGF-II (rM IGF-2/IGF-II; P09535Ala25-Glu91). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. IGF-2 and exhibited statistically significant, positive associations with colorectal cancer risk when cases were confined to those diagnosed within a relatively short period after enrolment. Circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer. IGF-2/IGF-II appears to be involved in the progression of many tumors. It binds to at least two different types of receptors: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumor suppressor function—it mediates IGF 2 degradation. Mutation of M6-P/IGF 2R causes both diminished growth suppression and augmented growth stimulation. This study aimed to investigate the role of IGF 2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Mouse IGF-2/IGF-II Protein |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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