购物车
- 全部删除
您的购物车当前为空
Anti-IGF2/IGF-II Antibody (1H183)
还可以产品编号 TMAY-03053
Anti-IGF2/IGF-II Antibody (1H183) 是一种 Rabbit 抗体，靶向 IGF2/IGF-II。Anti-IGF2/IGF-II Antibody (1H183) 可用于 ELISA。
Anti-IGF2/IGF-II Antibody (1H183)
Anti-IGF2/IGF-II Antibody (1H183)
还可以产品编号 TMAY-03053
Anti-IGF2/IGF-II Antibody (1H183) 是一种 Rabbit 抗体，靶向 IGF2/IGF-II。Anti-IGF2/IGF-II Antibody (1H183) 可用于 ELISA。
产品信息正在更新中，如果您想购买，请点击大包装&定制按钮.
大包装 & 定制
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-IGF2/IGF-II Antibody (1H183) is a Rabbit antibody targeting IGF2/IGF-II. Anti-IGF2/IGF-II Antibody (1H183) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1H183 |
| 交叉反应 | Mouse |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IGF-2/IGF-II (rM IGF-2/IGF-II; P09535Ala25-Glu91). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. IGF-2 and exhibited statistically significant, positive associations with colorectal cancer risk when cases were confined to those diagnosed within a relatively short period after enrolment. Circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer. IGF-2/IGF-II appears to be involved in the progression of many tumors. It binds to at least two different types of receptors: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumor suppressor function—it mediates IGF 2 degradation. Mutation of M6-P/IGF 2R causes both diminished growth suppression and augmented growth stimulation. This study aimed to investigate the role of IGF 2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse IGF-2/IGF-II Protein |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
评论列表
预览
Related Tags: buy Anti-IGF2/IGF-II Antibody (1H183) | purchase Anti-IGF2/IGF-II Antibody (1H183) | Anti-IGF2/IGF-II Antibody (1H183) cost | order Anti-IGF2/IGF-II Antibody (1H183)
嗨！有任何问题？点我咨询
评论内容