conjugate

Auristatin F 是一种有效的微管抑制剂和血管损伤剂。 Auristatin F 可用于抗体-药物偶联物。

ALC-0159 是聚乙二醇的脂质结合物，是一种疫苗赋形剂。

Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。

1V209 (TLR7 agonist T7) 是一种 Toll 样受体 7 (TLR7) 激动剂，可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性，具有抗肿瘤作用。

FAK ligand-Linker Conjugate 1 is a chemical compound designed to facilitate PROTAC-mediated protein degradation. This compound consists of a ligand specifically targeting FAK and a PROTAC linker module, which acts as a recruitment agent for E3 ligases including VHL, CRBN, MDM2, and IAP[1].

K-Ras ligand-Linker Conjugate 1 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, facilitating the recruitment of E3 ligases VHL, CRBN, MDM2, and IAP. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 4 is a chemical compound that combines a ligand for K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The compound has the potential to be used in the synthesis of PROTAC K-Ras Degrader-1, a powerful degrader of K-Ras that has been shown to exhibit a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 5 is a chemical compound that combines a ligand for the K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The K-Ras ligand-Linker Conjugate 5 plays a crucial role in the synthesis of PROTAC K-Ras Degrader-1, a highly potent K-Ras degrader. In SW1573 cells, this degrader exhibits an impressive degradation efficacy of ≥70% [1].

K-Ras ligand-Linker Conjugate 6 是一种结合 K-Ras 招募片段配体和PROTAC连接子的化合物,可募集 E3 连接酶,合成 PROTAC K-Ras Degrader-1.

E3 Ligase Ligand-linker Conjugate 114 属于E3 泛素酶配体+连接子偶联物类 (E3 Ligase Ligand-Linker Conjugates)。该化合物主要用于制备 PTOTAC HSD17B13 degrader 1。

E3 Ligase Ligand-linker Conjugate 116 属于 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 类别，主要应用于制备 PROTAC SMARCA2 4-degrader-28。

E3 Ligase Ligand-linker Conjugate 118 属于 E3 泛素酶配体+连接子偶联物类 (E3 Ligase Ligand-Linker Conjugates)。该化合物主要应用于制备 PROTAC SMARCA2 4-degrader-30。

E3 Ligase Ligand-Linker Conjugate 112 属于E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 类别，主要应用于制备 SMARCA2 degrader-10。

E3 Ligase Ligand-linker Conjugate 136 为 E3 泛素酶配体-连接子偶联物 (E3 Ligase Ligand-linker conjugate)，而 E3 Ligase Ligand-linker Conjugate 129 则可用于合成 c-Myc inhibitor7。

p62-ZZ Ligand-Linker Conjugate 1 是一种专用于合成 AUTOTACVinclozolinM2-2204 的 p62-ZZ 域配体-连接子结合物。

E3 Ligase Ligand-linker Conjugate 137 作为PROTAC METTL3-14 degrader 1的连接子和E3连接酶配体，主要用于急性髓性白血病的研究。

E3 Ligase Ligand-linker Conjugate 139 是一种专门用于癌症研究领域的E3 泛素连接酶配体和连接子，属于PROTACKB03-SLF。

E3 Ligase Ligand-linker Conjugate 133 作为合成完整PROTAC分子CPD-39中关键的中间体，其结构包含了E3 连接酶配体与接头 (conjugate of E3 ligase Ligand and linker) 的结合。

E3 Ligase Ligand-linker Conjugate 126，作为E3 连接酶配体-连接子偶联物，主要应用于合成PROTAC，如PROTAC BRM BRG1 degrader-1。

E3 Ligase Ligand-linker Conjugate 134，作为E3 连接酶配体与接头的复合体（conjugate of E3 ligase Ligand and linker），是制造PROTAC活性分子STING-IN-10的核心中间体。

E3 Ligase Ligand-linker Conjugate 129，一种E3泛素酶配体-连接子偶联物(E3 Ligase Ligand-linker conjugate)，主要用于DD205-291的合成。

E3 Ligase Ligand-linker Conjugate 125是一种用于合成PROTAC IRAK4degrader-12的E3泛素酶配体-连接子偶联物(E3 Ligase Ligand-linker Conjugate)。

E3 Ligase Ligand-linker Conjugate 120 为PROTAC PRMT3 degrader 1中的E3泛素连接酶配体与连接子的复合体。