DMPE-PEG550 is a PEG lipid with functional end groups designed for the synthesis of liposomes (LPs) and the creation of conjugated polymer nanoparticles. Liposome nanoparticles (LNPs) feature biotin modifications and carboxyl ends, allowing further coupling with other biomolecules. These functional nanoparticles are employed for targeted labeling of specific cell proteins. Using streptavidin as a linker, the biotinylated PEG lipid conjugate polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling applications in fluorescence-based imaging and sensing.