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Cefiderocol

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Cefiderocol
产品编号 T7585Cas号 1225208-94-5
别名 头孢地尔, S-649266, S649266, RSC649266, RSC 649266, GSK269626, GSK 269626

Cefiderocol (S-649266) 是一种一种新型铁载体-头孢菌素偶联物,具有抗菌活性,抑制有氧革兰氏阴性细菌,可用于研究细菌感染。

Cefiderocol

Cefiderocol

Rating icon 很棒
Cefiderocol
纯度: 98.46%
产品编号 T7585 别名 头孢地尔, S-649266, S649266, RSC649266, RSC 649266, GSK269626, GSK 269626Cas号 1225208-94-5

Cefiderocol (S-649266) 是一种一种新型铁载体-头孢菌素偶联物,具有抗菌活性,抑制有氧革兰氏阴性细菌,可用于研究细菌感染。

规格价格库存数量
1 mg
¥ 2,280
现货
5 mg
¥ 5,430
现货
10 mg
¥ 7,420
现货
25 mg
¥ 10,800
现货
大包装 & 定制
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TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
产品是否需要避光?
一般来说,如果有需要避光储存的分子,我们会选择棕色玻璃瓶发货的。
如何设置母液浓度?
母液浓度需低于官网给出的溶解度,在这个范围内,根据工作液浓度设置母液浓度,细胞实验中,建议母液浓度设定在工作液浓度的 1000 倍以上。
收到化合物后,是否需要称量后配制储备液?
对于小包装,如 1 mg、5 mg、10 mg 等,不建议二次称量。这样会导致化合物损耗,且无法估算。TargetMol 所有产品原装进口,精准称量,您收到后可直接添加相应量溶剂。 对于大包装,如果您需要分批次实验,可每次称量后配制储备液,建议您 10 mg 起称,称量的误差会小一些;当然条件允许,也可以先配制成高浓度母液,分装备用。
得到的杀死细胞的 IC50 与网页上 IC50 差距较大怎么办?
您所测试的IC50是指细胞的增殖抑制实验(半抑制率),细胞增殖抑制实验 IC50值,和网页上的靶点IC50其实是不同的意义。文献里和网页上 IC50其实往往是指对于靶点无细胞实验的抑制率,这样的实验一般是通过激酶或者蛋白纯化实验做出来的,nM 级别的浓度比较常见,但是细胞的增殖抑制实验 IC50 是指细胞的半致死率,同时牵涉到细胞的代谢以及渗透,一般浓度会高一些。 另外,同一个化合物对不同细胞模型的效果也是不同的,建议尝试增加孵育量、延长孵育时间。
Tween-20 可以用 Tween-80 替代吗?
不建议使用 Tween-20。相较于 Tween-20,Tween-80 的耐受性更好,Tween-80已被用作评估实验药物和毒物的行为影响的工具,且没有明显的副作用。 参考文献:Castro CA, Hogan JB, Benson KA, Shehata CW, Landauer MR. Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620. Pharmacol Biochem Behav. 1995 Apr;50(4):521-6.
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选择批次:
纯度:98.46%
联系我们获取更多批次信息

产品介绍

生物活性
产品描述
Cefiderocol (S-649266) is a novel iron-siderophore-cephalosporin conjugate with antibacterial activity, inhibiting aerobic Gram-negative bacteria, used in bacterial infection research.
体外活性
Cefiderocol 对 CRAB 表现出优异的抗菌活性。[1]
别名头孢地尔, S-649266, S649266, RSC649266, RSC 649266, GSK269626, GSK 269626
化学信息
分子量752.22
分子式C30H34ClN7O10S2
CAS No.1225208-94-5
SmilesC([O-])(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC(C(O)=O)(C)C)/C3=CSC(N)=N3)=O)C2=O)(SCC1C[N+]4(CCNC(=O)C5=C(Cl)C(O)=C(O)C=C5)CCCC4)[H]
密度1.31g/cm3
储存&溶解度
存储store at low temperature,keep away from moisture | store at -20°C | Shipping with blue ice.
溶解度信息
DMSO: 80 mg/mL (106.35 mM), Sonication is recommended. The compound is unstable in solution. Please use soon.
H2O: 1 mg/mL (1.33 mM), Sonication is recommended. The compound is unstable in solution. Please use soon.
溶液配制表
H2O/DMSO
1mg5mg10mg50mg
1 mM1.3294 mL6.6470 mL13.2940 mL66.4699 mL
DMSO
1mg5mg10mg50mg
5 mM0.2659 mL1.3294 mL2.6588 mL13.2940 mL
10 mM0.1329 mL0.6647 mL1.3294 mL6.6470 mL
20 mM0.0665 mL0.3323 mL0.6647 mL3.3235 mL
50 mM0.0266 mL0.1329 mL0.2659 mL1.3294 mL
100 mM0.0133 mL0.0665 mL0.1329 mL0.6647 mL

SCI 文献

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O, 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

参考文献

1.Zhao Y, et al. MEK inhibitor, PD98059, promotes breast cancer cell migration by inducing β-catenin nuclear accumulation. Oncol Rep. 2017 Nov;38(5):3055-3063.2.Chen S, et al. Reversing multidrug resistance in hepatocellular carcinoma cells by inhibiting extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activity. Oncol Lett. 2014 Nov;8(5):2333-2339.3.Di Paola R, et al. PD98059, a specific MAP kinase inhibitor, attenuates multiple organ dysfunction syndrome/failure (MODS) induced by zymosan in mice. Pharmacol Res. 2010 Feb;61(2):175-87.4.Ahmad SF, et al. MAP kinase inhibitor PD98059 regulates Th1, Th9, Th17, and natural T regulatory cells in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Eur J Pharmacol. 2023 Nov 15;959:176086.5.Yeh H T, Tsai Y S, Chen M S, et al. Flavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells[J]. European Journal of Pharmacology. 2019: 172658.6.Chen M S, Lin W C, Yeh H T, et al. Propofol specifically reduces PMA-induced neutrophil extracellular trap formation through inhibition of p-ERK and HOCl[J]. Life sciences. 2019 Mar 15;221:178-186.7.Hu, Qiuhui, Hengjun Du, Gaoxing Ma, Fei Pei, Ning Ma, Biao Yuan, Paul A. Nakata, and Wenjian Yang. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii [J]. Food Funct. 2018 Jul 17;9(7):3764-3775.8.Chen M S, Yeh H T, Li Y Z, et al. Flavopereirine Inhibits Autophagy via the AKT/p38 MAPK Signaling Pathway in MDA-MB-231 Cells[J]. International Journal of Molecular Sciences. 2020, 21(15): 5362.9.Zheng Y, Wang Y, Zhang X, et al. C19, a C-terminal peptide of CKLF1, decreases inflammation and proliferation of dermal capillaries in psoriasis[J]. Scientific Reports. 2017 Oct 24;7(1):13890.10.Dong L, Gong J, Wang Y, et al. Chiral geometry regulates stem cell fate and activity[J]. Biomaterials. 2019: 119456.

文献引用

1.Xu X, Song L, Li Y, et al.Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway.Journal of Translational Medicine.2023, 21(1): 1-20.2.Zou X, Zeng M, Zheng Y, et al.Comparative Study of Hydroxytyrosol Acetate and Hydroxytyrosol in Activating Phase II Enzymes.Antioxidants.2023, 12(10): 1834.3.Urade R, Chang W T, Ko C C, et al.A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy.Life Sciences.2023: 121835.4.Liu Y, Yuan C, Zhou M, et al. Co-cultured Bone-marrow Derived and Tendon Stem Cells: Novel Seed Cells for Bone Regeneration. Open Life Sciences. 2019, 14(1): 568-5755.Chen M S, Yeh H T, Li Y Z, et al. Flavopereirine Inhibits Autophagy via the AKT/p38 MAPK Signaling Pathway in MDA-MB-231 Cells. International Journal of Molecular Sciences. 2020, 21(15): 53626.Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.7.Dong L, Gong J, Wang Y, et al. Chiral geometry regulates stem cell fate and activity. Biomaterials. 2019: 119456.8.Su J W, Li S F, Tao J J, et al. Estrogen protects against acidosis-mediated articular chondrocyte injury by promoting ASIC1a protein degradation. European Journal of Pharmacology. 2021: 174381.9.Hu Q, Du H, Ma G, et al. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii. Food & Function. 2018, 9(7): 3764-377510.Chen M S, Tung Y W, Hu C L, et al. Three Lipid Emulsions Reduce Staphylococcus aureus-Stimulated Phagocytosis in Mouse RAW264. 7 Cells. Microorganisms. 2021, 9(12): 2479.11.Chen M S, Lin W C, Yeh H T, et al. Propofol specifically reduces PMA-induced neutrophil extracellular trap formation through inhibition of p-ERK and HOCl. Life Sciences. 2019 Mar 15;221:178-18612.Li S, Deng G, Su J, et al. A novel all-trans retinoic acid derivative regulates cell cycle and differentiation of myelodysplastic syndrome cells by USO1. European Journal of Pharmacology. 2021: 174199.13.Liu Z, Yang J. Uncarboxylated osteocalcin promotes osteogenic differentiation of mouse bone marrow–derived mesenchymal stem cells by activating the Erk‐Smad/β‐catenin signalling pathways. Cell Biochemistry and Function. 201914.Chen M S, Yang K S, Lin W C, et al. Lipofundin mediates major inhibition of intravenous propofol on phorbol myristate acetate and Escherichia coli-induced neutrophil extracellular traps. Molecular Biology Reports. 2022: 1-1315.Yeh H T, Tsai Y S, Chen M S, et al. Flavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells. European Journal of Pharmacology. 2019, 863: 17265816.Zheng Y, Wang Y, Zhang X, et al. C19, a C-terminal peptide of CKLF1, decreases inflammation and proliferation of dermal capillaries in psoriasis. Scientific Reports. 2017, 7(1): 1-1117.Yang Z, Guo D, Zhao J, et al.Aggf1 Specifies Hemangioblasts at the Top of Regulatory Hierarchy via Npas4l and mTOR-S6K-Emp2-ERK Signaling.Arteriosclerosis, Thrombosis, and Vascular Biology.202318.Kong F, Liu H, Xu T, et al.RG108 attenuates acute kidney injury by inhibiting P38 MAPK/FOS and JNK/JUN pathways.International Immunopharmacology.2024, 142: 113077.19.Guo K, Gao L, Li P, et al.Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling.IBRO Neuroscience Reports.202520.Gao K, Si M, Qin X, et al.Transcription factor XBP1s promotes endometritis-induced epithelial-mesenchymal transition by targeting MAP3K2, a key gene in the MAPK/ERK pathway.Cell Communication and Signaling.2025, 23(1): 72.

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