Name: Trastuzumab duocarmazine
Brand: TargetMol
SKU: T80955
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

待询

5 mg

待询

生物活性

产品描述	Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is an ADC targeting HER2 that undergoes cleavage by histone B within tumor cells, thereby achieving selective targeting of these cells. It exhibits antitumor activity and is applicable in cancer research, particularly concerning uterine and ovarian sarcomas [1].
体外活性	Trastuzumab duocarmazine（SYD985）（0.0001-100 μg/mL，24小时内）对HER2-和HER2+细胞都呈现出显著的细胞毒性。与T-DM1对HER2/NEU 3+细胞系的IC50值0.096 μg/mL相比，SYD985的细胞毒性增强了约7倍，IC50值降至0.013 μg/mL。而在HER2/NEU 1+细胞中，SYD985相较T-DM1显示出更高效的杀伤力，其IC50值是后者的54倍[1]。
体内活性	Trastuzumab duocarmazine (SYD985) (3 mg/kg或10 mg/kg，i.v.，单次) 能够有效抑制肿瘤生长，延长小鼠生存时间，显示出显著的体内抗肿瘤效果[1]。
别名	(vic)-Trastuzumab duocarmazine
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
内毒素	＜ 1.0 EU/mg

抗原信息

靶点

HER2

化学信息

CAS No.

1642152-40-6

储存&溶解度

存储	-20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Trastuzumab duocarmazine