Name: PhAc-ALGP-Dox
Brand: TargetMol
SKU: TP2980
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	PhAc-ALGP-Dox is a peptide-drug conjugate and a novel antitumor prodrug. It exhibits a range of IC50 values from 311 nM to 34.25 μM against TNBC (E0771), normal mouse epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human colorectal cancer (LS 174T), and normal human epithelium (HME-1) cells.
体外活性	PhAc-ALGP-Dox 通过肿瘤特异性的双步骤切割过程依次被激活，最初由细胞外的 THOP1 引发切割，接着由 FAPα/DPP4 进一步处理。

化学信息

分子量	1003.94
分子式	C₄₅H₅₈N₅O₁₉P
CAS No.	1616592-31-4
Smiles	OC=1C2=C([C@@H](O[C@H]3C[C@H](NC(=O)[C@H]4N(C(CNC([C@@H](NC([C@@H](NC(CP(=O)(O)O)=O)C)=O)CC(C)C)=O)=O)CCC4)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6
Sequence	{Phosphonoacetyl}-Ala-Leu-Gly-Pro-{Dox}
Sequence Short	{Phosphonoacetyl}-ALGP-{Dox}

储存&溶解度

存储	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

PhAc-ALGP-Dox