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p38 MAPK

p38 MAPK

p38 MAPKs (α, β, γ, and δ) are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/6, the p38 MAPK kinases. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. p38 MAPK is involved in regulation of HSP27, MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and several transcription factors including ATF-2, Stat1, the Max/Myc complex, MEF-2, Elk-1, and indirectly CREB via activation of MSK1.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T38665 OVA-E1 peptide TFA
化合物OVA-E1 peptide TFA
1262750-80-0
OVA-E1 peptide TFA 在突变型和野生型胸腺细胞中都能同样地激活 p38 和 JNK 级联。
TN3404 Altholactone
化合物 TN3404
65408-91-5 98%
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN4394 Kobophenol A
化合物 TN4394
124027-58-3 98%
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TN3042 4-Hydroxycinnamamide
化合物 TN3042
194940-15-3 98%
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN4938 Samidin
化合物 TN4938
477-33-8 98%
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
T78652 P38α inhibitor 4
化合物 p38α inhibitor 4
1262406-08-5 98%
p38α inhibitor4(化合物10)作为一种选择性变构p38α抑制剂,呈现出对p38α的高度选择性,其IC50值为1.2 μM。该化合物对p38β、p38γ及p38δ均无活性。
T78838 Akt/NF-κB/MAPK-IN-1
化合物 Akt/NF-κB/MAPK-IN-1
98%
Akt/NF-κB/MAPK-IN-1(compound 2m)为口服活性NO抑制剂,IC50值为7.70 μM,低毒性。该化合物通过抑制Akt/NF-κB与MAPK信号通路实现抗炎效应。
T79028 P38 Kinase inhibitor 4
化合物 p38 Kinase inhibitor 4
13142-47-7 98%
p38 Kinase inhibitor 4 (compound 135) 是高效的 p38 MAP Kinase 抑制剂,具有显著的生物活性。
T80631 Esculin sesquihydrate
化合物 Esculin sesquihydrate
66778-17-4 98%
Esculin sesquihydrate为荧光香豆素葡萄糖苷类化合物,源自灰树皮有效成分。该化合物可经MAPK信号通路改善实验性糖尿病肾病(DN)的认知障碍,并具有抗氧化应激及抗炎效应。
T81441 PLK1/p38γ-IN-1
化合物 PLK1/p38γ-IN-1
2418614-81-8 98%
PLK1/p38γ-IN-1(化合物14)为PLK1与p38γ多靶点抑制剂,体外有效抑制人肝细胞癌与肝母细胞瘤细胞增殖。
T81598 Org OD 02-0
化合物 Org OD 02-0
13258-85-0 98%
Org OD 02-0(10-Ethenyl-19-norprogesterone)为mPRα(膜孕酮受体α)特异性激动剂,IC50值为33.9 nM。该化合物能够激活MAPK活性,并且能抑制催乳素(PRL)的分泌。
TN4317 Isopedicin
化合物 TN4317
4431-42-9 98%
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
TN5011 Shizukaol B
化合物 TN5011
142279-40-1 98%
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T7162 R1487 Hydrochloride
化合物R1487 (Hydrochloride)
449808-64-4 98%
R1487 Hydrochloride (R1487(Hydrochloride)) 是一种可口服的高选择性 p38α 抑制剂,对 p38α 和 p38β 的Kd 值分别为 0.2 nM 和 29 nM。
T10298 AMG-548 hydrochloride (864249-60-5 free base)
化合物 T10298
T10298 98%
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective a...
TN4774 Physalin A
化合物 TN4774
23027-91-0 98%
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN1751 Hydroxycitric acid
2-羟基柠檬酸
6205-14-7 98%
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
TN1347 8-Prenylkaempferol
化合物8-Prenylkaempferol
28610-31-3 98%
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
TN4986 Selinidin
化合物 TN4986
19427-82-8 98%
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
TN5174 Trichosanatine
化合物 TN5174
169626-16-8 98%
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
OVA-E1 peptide TFA
T38665
OVA-E1 peptide TFA 在突变型和野生型胸腺细胞中都能同样地激活 p38 和 JNK 级联。
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
Kobophenol A
TN4394
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
4-Hydroxycinnamamide
TN3042
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
Samidin
TN4938
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
p38α inhibitor 4
T78652
p38α inhibitor4(化合物10)作为一种选择性变构p38α抑制剂,呈现出对p38α的高度选择性,其IC50值为1.2 μM。该化合物对p38β、p38γ及p38δ均无活性。
Akt/NF-κB/MAPK-IN-1
T78838
Akt/NF-κB/MAPK-IN-1(compound 2m)为口服活性NO抑制剂,IC50值为7.70 μM,低毒性。该化合物通过抑制Akt/NF-κB与MAPK信号通路实现抗炎效应。
p38 Kinase inhibitor 4
T79028
p38 Kinase inhibitor 4 (compound 135) 是高效的 p38 MAP Kinase 抑制剂,具有显著的生物活性。
Esculin sesquihydrate
T80631
Esculin sesquihydrate为荧光香豆素葡萄糖苷类化合物,源自灰树皮有效成分。该化合物可经MAPK信号通路改善实验性糖尿病肾病(DN)的认知障碍,并具有抗氧化应激及抗炎效应。
PLK1/p38γ-IN-1
T81441
PLK1/p38γ-IN-1(化合物14)为PLK1与p38γ多靶点抑制剂,体外有效抑制人肝细胞癌与肝母细胞瘤细胞增殖。
Org OD 02-0
T81598
Org OD 02-0(10-Ethenyl-19-norprogesterone)为mPRα(膜孕酮受体α)特异性激动剂,IC50值为33.9 nM。该化合物能够激活MAPK活性,并且能抑制催乳素(PRL)的分泌。
Isopedicin
TN4317
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
Shizukaol B
TN5011
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
R1487 Hydrochloride
T7162
R1487 Hydrochloride (R1487(Hydrochloride)) 是一种可口服的高选择性 p38α 抑制剂,对 p38α 和 p38β 的Kd 值分别为 0.2 nM 和 29 nM。
AMG-548 hydrochloride (864249-60-5 free base)
T10298
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective a...
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
Hydroxycitric acid
TN1751
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
8-Prenylkaempferol
TN1347
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
Selinidin
TN4986
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
Trichosanatine
TN5174
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
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