PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product Name	CAS No.	Purity
T4480	Vardenafil dihydrochloride 二盐酸伐地那非	224789-15-5	99.77%
T4480	Vardenafil dihydrochloride (Levitra) 是一种新型 PDE 抑制剂，对 PDE5 和 PDE1 的 IC50 分别为 0.7 和 180 nM。
TN2217	Sophoflavescenol 槐苦参醇	216450-65-6	99.65%
TN2217	Sophoflavescenol 是异戊烯基黄酮类化合物，能够抑制PDE5的活性，IC50=0.013 μM。它也抑制 RLAR，HRAR，BACE1，AChE 和 BChE，IC50值分别为 0.30 µM，0.17 µM，10.98 µM，8.37 µM 和 8.21 µM。
T19706	Ro 20-1724 化合物Ro20-1724	29925-17-5	98.82%
T19706	Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV)，其 Ki=1930 nM，具有神经保护作用。
T12315	OR-1896 化合物 T12315	220246-81-1	98%
T12315	OR-1896 is an active long-lived Levosimendan metabolite, is a highly selective inhibitor of phosphodiesterase (PDE) III isoformand a powerful vasodilator.
T22491	PDE7-IN-2 化合物 PDE7-IN-2	107522-19-0	98%
T22491	PDE7-IN-2 是磷酸二酯酶 7 (IC50 = 2.1 µM) 的抑制剂，可用于帕金森病研究。
T10994	Deltasonamide 2 化合物 T10994	2088485-34-9	98%
T10994	Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
T12394	PDE5-IN-2 化合物 T12394	2244517-61-9	98%
T12394	PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
T16484	PF-05180999 化合物 T16484	1394033-54-5	98%
T16484	PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM).
TN2095	Pomiferin 橙桑黄酮	572-03-2	98%
TN2095	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
T16434	PAT-048 化合物 T16434	1359983-15-5	98%
T16434	PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no ef...
TN2974	3-O-Methylquercetin tetraacetate 化合物 TN2974	1486-69-7	98%
TN2974	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
T10994L	Deltasonamide 2 hydrochloride 化合物 T10994L	T10994L	98%
T10994L	Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.
TN4317	Isopedicin 化合物 TN4317	4431-42-9	98%
TN4317	Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
T14962	CI-1044 化合物 T14962	197894-84-1	98%
T14962	CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).
TN4397	Kuraridine 次苦参素	34981-25-4	98%
TN4397	Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
T11483	GSK256066 Trifluoroacetate 化合物 T11483	1415560-64-3	98%
T11483	GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of ch...
T11206	Ent-Tadalafil 化合物 T11206	629652-72-8	98%
T11206	ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).
T16482	PF-05085727 化合物 T16482	1415637-72-7	98%
T16482	PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11. PF-05085727 is an effective, selective and brain penetrant inhibitor of cGMP-dependent ...
T10418	Autotaxin modulator 1 化合物 T10418	1548743-69-6	98%
T10418	Autotaxin modulator 1 is a new modulator of Autotaxin.
TN4665	Norbraylin 化合物 TN4665	60796-64-7	98%
TN4665	Norbraylin is a natural product from Toddalia asiatica.