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Search Results for " akt "

Targets Recommended: Akt Akt

374

抑制剂 & 化合物

164

天然产物

6

化合物库

5

TargetMol 试剂盒

40

重组蛋白

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Cat. No.	Product Name
L1300	PI3K/Akt/mTOR 化合物库		420 compounds
	420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合，用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选；
L3400	临床期小分子药物库		3404 compounds
	3404 个临床期化合物集合，可用于高通量筛选和高内涵筛选；
L2195	抗前列腺癌化合物库		2070 compounds
	2070 种与前列腺癌相关的化合物，可以用于高通量和高内涵筛选
L2193	抗肝癌化合物库		1787 compounds
	1787 种与肝癌相关的化合物，可以用于抗肝癌药物研发和药理研究；
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；

化合物库

PI3K/Akt/mTOR 化合物库

Cat.No: L1300

Compounds: 420

临床期小分子药物库

Cat.No: L3400

Compounds: 3404

抗前列腺癌化合物库

Cat.No: L2195

Compounds: 2070

抗肝癌化合物库

Cat.No: L2193

Compounds: 1787

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

Cat. No.	Product Name	Form	Specificity Of Inhibition
CL0102	Akt inhibitor/activator kit Akt inhibitor/activator kit
CL0121	ALK inhibitor kit ALK inhibitor kit
CL0141	Notch pathway inhibitor kit Notch pathway inhibitor kit
CL0075	c-Kit inhibitor kit c-Kit inhibitor kit
CL0094	FLT3 inhibitor kit FLT3 inhibitor kit

TargetMol 试剂盒

Akt inhibitor/activator kit

Cat.No: CL0102

ALK inhibitor kit

Cat.No: CL0121

Notch pathway inhibitor kit

Cat.No: CL0141

c-Kit inhibitor kit

Cat.No: CL0075

FLT3 inhibitor kit

Cat.No: CL0094

Cat. No.	Product Name	Target	Signaling Pathways
T10276L	AKT Kinase Inhibitor HCl AKT Kinase Inhibitor HCl(842148-40-7 Free base)	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT Kinase Inhibitor HCl 是一种 Akt 抑制剂，具有抗肿瘤活性。
T36310	AKT-IN-6 INCB-047775	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-6 (INCB-047775)对ATK 有抑制作用。Akt 是对生长因子、细胞因子和其他细胞刺激的细胞信号传导的重要组成部分。Akt 的异常激活与2型糖尿病和癌症的发生密切相关。
T10276	AKT Kinase Inhibitor	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 抑制剂，以剂量依赖的方式选择性抑制细胞增殖。
T25017	AKT-I-1	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-I-1 是一种特异性和可逆的 Akt1 抑制剂。
T23695	Akt-I-1,2	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Akt-I-1,2 是 Akt1 和 Akt2 的选择性抑制剂。
T3346	AKT inhibitor VIII AKTi-1/2	Apoptosis; Akt	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT inhibitor VIII (AKTi-1/2) 是一种细胞渗透的喹喔啉化合物，可逆的选择性抑制Akt1、Akt2和Akt3的活性，IC50值分别为 58 nM、210 nM 和 2119 nM。
T9393	(E)-Akt inhibitor-IV (E)-AKTIV,CS-1992	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	(E)-Akt inhibitor-IV ((E)-AKTIV) 是PI3K-Akt 抑制剂，表现出明显的细胞毒性。
T4489	AKT-IN-1 AZD26,AZD-26,6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺,AZD 26	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-1 (AZD-26) 是一种变构的 AKT 抑制剂，其 IC50=1.042 μM。
T5508	PF-AKT400 (S)-N-[[3-氨基-1-(5-乙基-7H-吡咯并[2,3-D]嘧啶-4-基)吡咯烷-3-基]甲基]-2,4-二氟苯甲酰胺,AKT protein kinase inhibitor	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	PF-AKT400 (AKT protein kinase inhibitor) 是 ATP 竞争性的、选择性的 Akt 抑制剂，对 PKBα(IC50=0.5 nM) 的选择性比 PKA(IC50=450 nM) 高 900 倍。
T3467	Miransertib ARQ-092,AKT inhibitor 2	Akt; Parasite	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Miransertib (ARQ-092) 是一种具有口服活性的，选择性和变构性Akt 抑制剂。它有效抑制利什曼原虫，还是 AKT1-E17K 突变蛋白抑制剂，可研究PI3K/AKT 驱动的肿瘤和 Proteus 综合征。
T23694	Akt Inhibitor X aktX,CCG 206734,Akt Inhibitor-X,CCG-206734,10-DEBC hydrochloride
	Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation.
T60564	PI3K/Akt/mTOR-IN-2	Apoptosis; Akt; PI3K; mTOR	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	PI3K/Akt/mTOR-IN-2 是一种有效的 PI3K/AKT/mTOR 抑制剂。PI3K/Akt/mTOR-IN-2 具有抗癌作用，并对 MDA-MB-231 细胞具有选择性，IC50 为 2.29 μM。PI3K/Akt/mTOR-IN-2 具有抗癌活性，可诱导癌细胞周期阻滞和细胞凋亡 (apoptosis)。
TP2175	Akt/SKG Substrate Peptide	Others	Others
	substrate for Akt/PKB
T10274	AKT-IN-2	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).
T10275	AKT-IN-3	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1
T71272	PI3K/Akt-IN-C89
	PI3K/Akt-IN-C89 is a novel Inhibitor of the PI3K-Akt Pathway, Inducing Autophagy of Female Germline Stem Cells.
T78913	AKT-IN-18	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-18是一款Akt抑制剂，其在A549细胞中展现出抑制Akt活性的能力，具有IC50为69.45 μΜ。该化合物能够诱导细胞凋亡(apoptosis)，适用于非小细胞肺癌(NSCLC)的研究领域。
T63211	AKT-IN-10
	AKT-IN-10 是有效的 AKT 抑制剂，对乳腺癌和前列腺癌表现出研究潜力。其中蛋白激酶 B (PKB，也称为 AKT) 是细胞中 PI3K/AKT/mTOR 信号传导的核心，其功能对细胞生长、存活、分化和代谢很重要。
T63653	AKT-IN-11
	AKT-IN-11 是有效的抗人肝癌 Bel-7402 细胞株抗菌剂之一 (IC50: 1.15 μM)。
T62807	AKT-IN-7
	AKT-IN-7 (compound 1-P1) 是一种 AKT 的有效抑制剂。AKT-IN-7 具有潜力进行癌症的研究。
T62771	AKT-IN-9
	AKT-IN-9 是一种 AKT 的有效抑制剂。其中蛋白激酶 B (PKB，也称为 AKT) 是细胞中 PI3K/AKT/mTOR 信号传导的核心，在细胞生长、存活、分化和代谢中发挥着重要用处。AKT-IN-9 具有潜力进行乳腺癌和前列腺癌的研究。
T63039	AKT-IN-13
	AKT-IN-13 (compound 4b) 是一种 Akt 的有效抑制剂，能够作用于 Akt1 (IC50: 1.6 nM)、Akt2 (IC50: 2.4 nM) 和 Akt3 (IC50: 0.3 nM) 。AKT-IN-13 能够用于研究抗癌。
T64603	Akt Antibody #9272R
	Akt Antibody #9272R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64603。
T62842	AKT-IN-8
	AKT-IN-8 是一种 AKT 的有效抑制剂，能够作用于 AKT1 (IC50: 4.46 nM)、AKT2 (IC50: 2.44 nM) 和 AKT3 (IC50: 9.47 nM)。
T61680	AKT-IN-5
	AKT-IN-5 (Example 8) is a chemical compound known as an Akt inhibitor, specifically targeting Akt1 and Akt2. Its potency is reflected in IC50 values of 450 nM and 400 nM for Akt1 and Akt2, respectively [1].
T62997	PI3K/AKT-IN-1
	PI3K/AKT-IN-1 是一种有效的、双重的 PI3K/AKT 抑制剂，能够作用于 PI3Kγ (IC50: 6.99 μM)、PI3Kδ (IC50: 4.01 μM) 和 AKT (IC50: 3.36 μM)。PI3K/AKT-IN-1 通过抑制 PI3K/AKT 通路，诱导 caspase 3 依赖性凋亡，表现出抗癌作用。
T61756	APN/AKT-IN-1
	APN/AKT-IN-1 is a potent dual inhibitor of aminopeptidase N (APN) and protein kinase B (AKT), exhibiting IC50 values of 0.21 μM and 0.27 μM for APN and AKT inhibition, respectively. This compound effectively suppresses the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), which serves as an intracellular substrate of AKT [1].
T72104	AKT Kinase Inhibitor hydrochloride
	AKTKinase Inhibitor hydrochloride 是一种具有抗肿瘤活性的Akt 抑制剂。
T79905	Akt/ROCK-IN-1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Akt/ROCK-IN-1 (B12) 是Akt和ROCK的双重抑制剂，IC50值分别为0.023 nM和1.47 nM。该化合物对神经母细胞瘤表现出抗肿瘤活性。
T72880	PI3K/AKT-IN-2
	PI3K/AKT-IN-2 是一种 PI3K 和 AKT 抑制剂。PI3K/AKT-IN-2 阻断上皮-间质转化 (EMT)，诱导细胞凋亡 (apoptosis)。PI3K/AKT-IN-2 抑制微管蛋白 (tubulin) 的聚合。
T64583	Phospho-Akt (Ser473) Antibody #9271R
	Phospho-Akt (Ser473) Antibody #9271R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64583。
T75719	Akt/SKG Substrate Peptide TFA
	Akt/SKG Substrate Peptide TFA 是一种合成的 Akt/PKB 底物肽，不会被 p70S6K 或 MAPK1 磷酸化。
T8427	Borussertib	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Borussertib 是一种蛋白激酶 Akt 的共价变构抑制剂，其对 Aktwt 的 IC50=0.8 nM，Ki=2.2 nM。
T63455	PI3K/Akt/mTOR-IN-3
	PI3K/Akt/mTOR-IN-3 是 PI3K/Akt/mTOR 的有效抑制剂。PI3K/Akt/mTOR-IN-3 能够抑制 MCF-7 细胞 (IC50: 0.77 μM)、HeLa 细胞 (IC50: 1.23 μM) 和 HepG2 细胞(IC50: 4.57 μM)。PI3K/Akt/mTOR-IN-3 在 4 μM 浓度下可抑制 MCF-7 和 HeLa 细胞的迁移。PI3K/Akt/mTOR-IN-3 能够将细胞周期阻滞在 S 期，并诱导细胞凋亡 (apoptosis)。
T72227	PI3K/Akt/CREB activator 1
	PI3K/Akt/CREB activator 1 是一种口服有效的PI3K/Akt/CREB 的激活剂。PI3K/Akt/CREB activator 1 通过 PI3K/Akt/CREB 通路上调脑源性神经营养因子，促进神经元增殖，诱导 Neuro-2a 细胞分化成神经元样形态，加速海马原代神经元轴突-树突极化的建立。PI3K/Akt/CREB activator 1 可用于血管性痴呆 (VaD) 的研究。
T14034	3CAI	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	3CAI 是特异性的AKT1和AKT2抑制剂。
T8969	API-1 NSC177223	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	API-1 (NSC-177223) 是Akt/PKB 抑制剂，可同 PH 结构域相结合并抑制 Akt 膜易位，有效降低 Akt 的磷酸化水平。它可选择性的抑制PKB，对 PKC 和 PKA 的激活无抑制作用。它可以和 TNF 相关的凋亡诱导配体协同作用从而诱导细胞凋亡。
T62078	Akt/NF-κB/JNK-IN-1
	Akt/NF-κB/JNK-IN-1 (Compound 2i) 是一种 Akt、NF-κB 和 JNK 信号通路抑制剂。Akt/NF-κB/JNK-IN-1 对一氧化氮的产生表现出抑制作用 (IC50: 3.15 μM)，表现出抗炎效果。
T78838	Akt/NF-κB/MAPK-IN-1	p38 MAPK	MAPK
	Akt/NF-κB/MAPK-IN-1（compound 2m）为口服活性NO抑制剂，IC50值为7.70 μM，低毒性。该化合物通过抑制Akt/NF-κB与MAPK信号通路实现抗炎效应。
T14072	A-443654	ERK; VEGFR; GSK-3; FLT; Casein Kinase; MAPK; Akt; PKA; Chk; CDK; Src; PKC; S6 Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	A-443654 是 pan-Akt 抑制剂，对Akt1，Akt2，和Akt3具有同等效力的抑制作用，Ki=均为 160 pM。
T7315	BAY1125976	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	BAY1125976 是选择性Akt1/Akt2变构抑制剂。在10 μM ATP 时，它抑制 Akt1 和 Akt2 活性的IC50值分别为 5.2 nM 和 18 nM。
T3132	SC66	Apoptosis; Akt	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	SC66 是一种Akt 抑制剂，可降低细胞活力。它以剂量和时间依赖性地抑制肝癌细胞的集落形成和诱导凋亡。
T34632	SH-5 SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II
	SH-5 是一种AKT抑制剂，通过抑制IκBα激酶激活调节的抗凋亡、增殖和转移基因产物，增强细胞凋亡并抑制侵袭。
T6139	A-674563 A674563	ERK; GSK-3; Akt; PKA; CDK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	A-674563 是一种口服有效，选择性的Akt1抑制剂，Ki=11 nM。
T1920	Capivasertib AZD5363	Akt; PKA; mTOR; Autophagy	Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Capivasertib (AZD5363) 是一种广谱的 AKT 抑制剂，对 Akt1、Akt2 和 Akt3 均有抑制活性 (IC50=3/7/7 nM)，具有口服活性。Capivasertib 具有抗肿瘤活性，可以用于治疗乳腺癌。
T27624	Iptakalim Hydrochloride	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Iptakalim hydrochloride 是一种亲脂性的对氨基化合物，是 ATP 敏感的钾通道的开放剂，也是含α4β2的烟碱乙酰胆碱受体拮抗剂。它也是一种 K(ir) 6.1/SUR2B 激活剂，可通过保护内皮功能减轻大鼠缺氧引起的肺动脉高压。
T2423	P7C3-A20	Others	Others
	P7C3-A20 是促神经原性和神经保护活性的 P7C3 衍生物。它具有抗抑郁活性，能够透过血脑屏障，并可用于研究脑损伤。
T2042	CTX-0294885	Others	Others
	CTx0294885 是新型的二苯胺嘧啶化合物，在体外对广泛激酶有抑制作用，可用作琼脂糖凝胶激酶检测试剂。
T13862	Recilisib RECILISIB 钠盐,Ex-RAD,ON 01210	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Recilisib (ON 01210) 是辐射防护剂，能够提高细胞中AKT 和PI3K 的活性。
T7953	BpV(HOpic) bpV (HOpic)	PTEN	PI3K/Akt/mTOR signaling
	BpV(HOpic) (bpV (HOpic)) 是 PTEN 选择性抑制剂，IC50=14 nM。BpV(HOpic) 具有神经保护作用。

化合物

AKT Kinase Inhibitor HCl

Cat.No: T10276L

Synonym: AKT Kinase Inhibitor HCl(842148-40-7 Free base)

Target: Akt

Cat.No: T36310

Synonym: INCB-047775

Target: Akt

AKT Kinase Inhibitor

Cat.No: T10276

Target: Akt

Cat.No: T25017

Target: Akt

Cat.No: T23695

Target: Akt

AKT inhibitor VIII

Cat.No: T3346

Synonym: AKTi-1/2

Target: Apoptosis, Akt

(E)-Akt inhibitor-IV

Cat.No: T9393

Synonym: (E)-AKTIV,CS-1992

Target: Akt

Cat.No: T4489

Synonym: AZD26,AZD-26,6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺,AZD 26

Target: Akt

Cat.No: T5508

Synonym: (S)-N-[[3-氨基-1-(5-乙基-7H-吡咯并[2,3-D]嘧啶-4-基)吡咯烷-3-基]甲基]-2,4-二氟苯甲酰胺,AKT protein kinase inhibitor

Target: Akt

Cat.No: T3467

Synonym: ARQ-092,AKT inhibitor 2

Target: Akt, Parasite

Akt Inhibitor X

Cat.No: T23694

Synonym: aktX,CCG 206734,Akt Inhibitor-X,CCG-206734,10-DEBC hydrochloride

PI3K/Akt/mTOR-IN-2

Cat.No: T60564

Target: Apoptosis, Akt, PI3K, mTOR

Akt/SKG Substrate Peptide

Cat.No: TP2175

Target: Others

Cat.No: T10274

Target: Akt

Cat.No: T10275

Target: Akt

PI3K/Akt-IN-C89

Cat.No: T71272

Cat.No: T78913

Target: Akt

Cat.No: T63211

Cat.No: T63653

Cat.No: T62807

Cat.No: T62771

Cat.No: T63039

Akt Antibody #9272R

Cat.No: T64603

Cat.No: T62842

Cat.No: T61680

PI3K/AKT-IN-1

Cat.No: T62997

Cat.No: T61756

AKT Kinase Inhibitor hydrochloride

Cat.No: T72104

Akt/ROCK-IN-1

Cat.No: T79905

Target: ROCK

PI3K/AKT-IN-2

Cat.No: T72880

Phospho-Akt (Ser473) Antibody #9271R

Cat.No: T64583

Akt/SKG Substrate Peptide TFA

Cat.No: T75719

Cat.No: T8427

Target: Akt

PI3K/Akt/mTOR-IN-3

Cat.No: T63455

PI3K/Akt/CREB activator 1

Cat.No: T72227

Cat.No: T14034

Target: Akt

Cat.No: T8969

Synonym: NSC177223

Target: Akt

Akt/NF-κB/JNK-IN-1

Cat.No: T62078

Akt/NF-κB/MAPK-IN-1

Cat.No: T78838

Target: p38 MAPK

Cat.No: T14072

Target: ERK, VEGFR, GSK-3, FLT, Casein Kinase, MAPK, Akt, PKA, Chk, CDK, Src, PKC, S6 Kinase

Cat.No: T7315

Target: Akt

Cat.No: T3132

Target: Apoptosis, Akt

Cat.No: T34632

Synonym: SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II

Cat.No: T6139

Synonym: A674563

Target: ERK, GSK-3, Akt, PKA, CDK

Cat.No: T1920

Synonym: AZD5363

Target: Akt, PKA, mTOR, Autophagy

Iptakalim Hydrochloride

Cat.No: T27624

Target: Potassium Channel, AChR

Cat.No: T2423

Target: Others

Cat.No: T2042

Target: Others

Cat.No: T13862

Synonym: RECILISIB 钠盐,Ex-RAD,ON 01210

Target: Akt, PI3K

Cat.No: T7953

Synonym: bpV (HOpic)

Target: PTEN

Cat. No.	Product Name	Target	Signaling Pathways
T5654	Musk ketone	Others	Others
	Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性，因此可能被证明是有用的癌症化学保护剂。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
T7190	Actein	Apoptosis; Akt; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。
TN1891	Lupiwighteone	Apoptosis; BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Lupiwighteone 是一种广泛存在于野生植物中的异黄酮。它通过抑制 PI3K/Akt/mTOR 通路，诱导人乳腺癌细胞 caspase 依赖性和非依赖性凋亡，具有抗氧化、抗菌和抗癌作用。
TL0006	Cichoric Acid 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species; HIV Protease	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Cichoric Acid (Dicaffeoyltartaric acid) 是一种天然化合物，具有抗氧化作用。
TN1079	Deoxyelephantopin	NF-κB	NF-κB
	Deoxyelephantopin 是来自Elephantopus scaber 的，具有生物活性的天然倍半萜烯内酯，能够抑制NF-κB，MAPK，PI3K/Akt 和β-catenin 信号传导。它可广泛用于癌症方面的研究。
T6677	Sophocarpine	ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。
T5S0896	Loureirin A 龙血素 A,龙血素A	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Loureirin A 是一种黄酮类物质，从龙血树中分离得到，能够降低Akt 的磷酸化，具有抗血小板聚集作用。
T5S0658	Corynoxine 柯诺辛,柯诺辛碱	Autophagy	Autophagy
	Corynoxine 是从大叶钩藤中分离出的一种四环羟吲哚生物碱。它是一种自噬增强剂，可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。
T3844	Deltonin 三角叶薯蓣皂苷	ERK; Others; Akt; Endogenous Metabolite	Cytoskeletal Signaling; MAPK; Metabolism; Others; PI3K/Akt/mTOR signaling
	Deltonin 是从盾叶薯蓣中得到的一种甾体皂苷，抑制ERK1/2和AKT 的活化，具有抗肿瘤活性。
T17280	(Z)-Guggulsterone	Apoptosis; VEGFR; Akt	Angiogenesis; Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	(Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul 的成分，可通过引起细胞凋亡来抑制人前列腺癌细胞的生长，还可通过抑制VEGF-VEGF-R2-Akt 信号传导轴来抑制血管生成。
TN1433	Batatasin III	FAK; Others; Akt	Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。
T5S1982	Periplocin Periplocoside,杠柳毒苷	Apoptosis; Others	Apoptosis; Others
	Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径，具有促进伤口愈合的潜力。
T13803	N-Oleoyl glycine	Cannabinoid Receptor; Akt; Endogenous Metabolite; PPAR	Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; PI3K/Akt/mTOR signaling
	N-Oleoyl glycine 是一种脂氨酸。在 3T3-L1 脂肪细胞中，N-Oleoyl glycine 通过激活CB1受体和Akt 信号通路来刺激脂肪形成。
TN1644	Flavanomarein	Others	Others
	Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物，对糖尿病性肾病具有保护作用。它具有很好的抗氧化，降糖，降压和降血脂作用。
T6S0781	Phellodendrine 黄柏碱,Phallodendrin	Others; NF-κB; Akt	Cytoskeletal Signaling; NF-κB; Others; PI3K/Akt/mTOR signaling
	Phellodendrine (Phallodendrin) 是异喹啉生物碱，是黄柏皮层中的重要特征成分之一。它具有良好的抗氧化，抗炎作用。它通过调节AKT/NF-κB 途径抵抗 AAPH 诱导的氧化应激。
T3861	Isobavachalcone Corylifolinin,Isobacachalcone,补骨脂乙素	Apoptosis; Others; Reactive Oxygen Species; Akt; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Others; PI3K/Akt/mTOR signaling
	Isobavachalcone (Corylifolinin) 是来源于补骨脂的一种Akt 信号通路抑制剂，可诱导人类癌细胞凋亡，以IC50值为 7.92 μM 抑制 OVCAR-8 癌细胞生长，具有抗癌和抗增殖活性。它还能诱导 OVCAR-8 细胞中活性氧的产生。
T6817	Deguelin 鱼藤素,(-)-Deguelin,(-)-cis-Deguelin,魚藤素	Apoptosis; Akt; PI3K; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Deguelin ((-)-Deguelin) 是一种 PI3K/AKT 抑制剂，从 Mundulea sericea 家族植物中分离出来的鱼藤酮类天然产物。
T2798	Esculetin 秦皮乙素,二羟基香豆素,Aesculetin,Cichorigenin	Lipoxygenase; Akt; PI3K	Cytoskeletal Signaling; Metabolism; PI3K/Akt/mTOR signaling
	Esculetin (Cichorigenin) 是主要提取自水曲柳的树皮中的活性成分。它能够抑制PI3K/Akt 途径，阻碍血小板衍生生长因子诱导的气道平滑肌细胞表型转换。它具有抗氧化，抗炎和抗肿瘤的活性。
T2791	Pectolinarin 柳穿鱼叶苷,大蓟苷	Apoptosis; Others; NO Synthase; Prostaglandin Receptor; Interleukin	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Others
	Pectolinarin 抑制 IL-6和 IL-8分泌以及 PGE2和 NO 产生，可通过抑制 PI3K/Akt 途径来抑制细胞增殖和炎症反应并诱导凋亡，具有抗炎活性。
T7912	(−)-Myrtenal (1R)-(-)-桃金娘烯醛,桃金娘烯醛,(1R)-(−)-Myrtenal	Others	Others
	(−)-Myrtenal 是一种具有口服活性及抗肿瘤活性的萜烯。(-)-Myrtenal 作用于糖尿病大鼠的骨骼肌和肝脏，利用 Akt 增强 GLUT2 ，进而改善高血糖症。
T5S0506	Rotundic acid Rutundic acid,铁冬青酸	Apoptosis; Others; p38 MAPK; Akt; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Others; PI3K/Akt/mTOR signaling
	Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物，具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。
TN4761	Phellamurin	P-gp	Membrane transporter/Ion channel; Neuroscience
	Phellamurin 是一种来自黄檗叶的黄酮糖苷，可诱导细胞凋亡，具有抗肿瘤活性。它抑制肠道 P-糖蛋白，还抑制凤蝶的产卵。
TN1911	Marein 马里苷,马里甙	transporter; Akt; HDAC; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取，IRS/Akt/GSK-3β增加糖原合成，并通过Akt/FoxO1减少糖异生，从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用，还有抗氧化、降压、降血脂和抗糖尿病作用。
T6S0619	Pachymic acid 3-O-Acetyltumulosic acid,茯苓酸	ERK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Pachymic acid (3-O-Acetyltumulosic acid) 是来自茯苓的一种三萜，可抑制Akt 和ERK 信号传导途径。
T2746	Sophocarpine monohydrate 槐果碱,Sophocarpine,槐果碱水合物	Apoptosis; Influenza Virus; Akt; PI3K; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Sophocarpine monohydrate 是从传统草药苦参中提取的一种重要生物碱，具有抗肿瘤活性，可用于肝细胞癌，前列腺癌和结肠直肠癌。苦参具有抗病毒，抗肿瘤和抗炎等多种药理作用。
T3895	Polyphyllin I 重楼皂苷I,重楼皂甙	Apoptosis; Akt; JNK; PDK; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Polyphyllin I 是从七叶一枝花中提取的生物活性成分，具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂，也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬，G2/M 期阻滞和细胞凋亡。
TN1968	N-Feruloyloctopamine N-Feruloyloctopamine,N-阿魏酰章鱼胺	p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	N-Feruloyloctopamine 是从木本曼陀罗提取的一种天然产物，有抗氧化作用，可显著降低Akt 和p38 MAPK 磷酸化水平。
T5574	Guggulsterone Guggulsterone E&Z,香胶甾酮	Apoptosis; FXR; Akt; Caspase; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Guggulsterone (Guggulsterone E&Z) E&Z 是来自Commiphora wightii 树中树胶脂的植物甾醇。它通过下调抗细胞凋亡基因产物，调节细胞周期蛋白，激活caspases，JNK，抑制Akt，抑制多种肿瘤细胞的生长并诱导细胞凋亡。它是法尼醇 X 受体拮抗剂，可降低 CDCA 诱导的 FXR 活化。
T2S0500	Ilexsaponin A 毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1	Others	Others
	Ilexsaponin A (Ilexsaponin A1)1 是分离自冬凌草的根中，利用抗凋亡途径减轻缺血再灌注引起的心肌损伤。它能够减少心肌梗塞的大小，减少 LDH，AST 和 CK-MB 的血清水平，促进细胞活力并抑制缺氧/复氧心肌细胞的凋亡。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
T0760	Cholesterol Cholesterin,Cholesteryl alcohol,胆固醇	Estrogen Receptor/ERR; MRP; Endogenous Metabolite; ROR	Endocrinology/Hormones; Immunology/Inflammation; Metabolism
	Cholesterol (Cholesteryl alcohol) 属于天然产物，是哺乳动物中的主要固醇，是一种雌激素相关受体 α (ERRα) 的激动剂。Cholesterol 广泛存在于动物的细胞膜，也是合成几种重要荷尔蒙及胆酸的材料。
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
T3001	Honokiol 和厚朴酚,NSC 293100	ERK; HCV Protease; MEK; Akt; Autophagy	Autophagy; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Honokiol (NSC-293100) 是厚朴提取物的活性成分，靶向多种信号分子，具有抗氧化，抗炎，抗血管生成和抗癌活性。它可抑制 Akt 的激活并增强 ERK1/ERK2 的磷酸化。
T0724	Formononetin Biochanin B,Flavosil,刺芒柄花素,Formononetol	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Formononetin (Flavosil) 是一种 FGFR2抑制剂，IC50约为4.31 μM。它是一种 O-甲基化的异黄酮，是来自黄芪根的植物雌激素，可有效抑制血管生成和肿瘤生长。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T6427	Butein 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因	Apoptosis; EGFR; Others; PDE; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors
	Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂，也是蛋白酪氨酸激酶抑制剂，还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。
T2789	Scutellarin 黄岑素,野黄芩苷,Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide	Akt; HIV Protease; STAT	Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Scutellarin (Scutellarein-7-glucuronide) 是从黄芩中分离的黄酮，可抑制破骨细胞中 RANKL 介导的 MAPK 和 NF-κB 信号通路，并下调 HCC 细胞中的 STAT3/Girdin/Akt 信号通路。
T2790	Oridonin NSC-250682,Rubescenin,冬凌草甲素,Isodonol,Rubescensin A	Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Oridonin (NSC-250682) 是从Rabdosia rubescens 中得到的二萜，是一种AKT 抑制剂，对 AKT1 和 AKT2 的IC50值分别为 8.4 和 8.9 μM，具有抗菌、抗炎、抗肿瘤等功效。
T2P2810	Methyl Linoleate Linoleic acid methyl ester,亚油酸甲酯,Telfairic Acid methyl ester	Antioxidant	oxidation-reduction
	Methyl Linoleate (Telfairic Acid methyl ester) 是一种 Sageretia thea 果实的主要活性成分，能够下调小眼畸形相关转录因子和酪氨酸酶相关蛋白，是一种主要的抗黑色素生成化合物。
T5740	25(R,S)-Ruscogenin (25RS)鲁斯可皂苷元,(25RS)-Ruscogenin	Others; HIF	Angiogenesis; Chromatin/Epigenetic; Others
	25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路，抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达，阻碍肝癌转移。它能够抑制 TLR4信号通路，减轻 LPS 诱导的肺内皮细胞凋亡。
T4S21320	ISOGINKGETIN 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮	MMP; Others	Others; Proteases/Proteasome
	ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂，也是一种Pre-mRNA Splicing 抑制剂。
T2974	Cyclovirobuxine D 黄杨碱,CVB-D,Bebuxine,Cyclovirobuxin D,环维黄杨星D	Apoptosis; Others; Akt; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Cyclovirobuxine D (Bebuxine) 是中药黄杨的主要活性成分，可诱导自噬并减弱Akt 和mTOR 的磷酸化。它通过抑制细胞周期进程和诱导线粒体介导的细胞凋亡抑制癌细胞的增殖，有用于心肌梗死引起的心力衰竭的研究潜力。
T0392	Artemisinin Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine	HCV Protease; Ferroptosis; Akt; Parasite	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，是从青蒿植物的地上部分分离的一种抗疟疾药物。它有神经保护和抗癌作用。
TN3500	beta-Amyrone β-Amyron,β-香树脂酮	COX; AChR; PPAR; Antifection	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性，EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。
T0518	Methacycline hydrochloride Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Methacycline hydrochloride (Rondomycin) 是四环素抗生素，可抑制细菌蛋白质的合成。它是上皮-间质转化 (EMT) 抑制剂。它在体外可阻断 EMT，体内抑制纤维发生，不会直接影响 TGF-β1 Smad 信号传导。它是抗菌剂，有潜力研究肺纤维化。
T13265	Urolithin B 尿石素B,3-羟基-6H-苯并[C]苯并吡喃-6-酮	ERK; NF-κB; Akt; Endogenous Metabolite; JNK; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Urolithin B 是一种 ellagitannins 的肠道微生物代谢产物，具有抗炎和抗氧化作用。它也是骨骼肌质量的调节因子，通过减少 IκBα 的磷酸化和降解来抑制 NF-κB 活性，并抑制 JNK、ERK 和 Akt 的磷酸化，并增强 AMPK 的磷酸化。
T2P2806	Hederacolchiside A1 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13	Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。
T3981	Acacetin 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis; IAP; COX; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Neuroscience
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 是一种来自狗舌草的口服有效类黄酮。它停在 PI3Kγ 的 ATP 结合口袋中，可导致癌细胞周期停滞，并诱导细胞凋亡和自噬。它有抗癌和抗炎活性，有潜力研究疼痛相关疾病。
T3P2904	α-Linolenic acid Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸，人体无法合成，从种子油中分离得到。它可调节 PI3K/Akt 信号传导，影响血栓形成过程。它具有抗心律失常的特性，并且与心血管疾病和癌症等有关。
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天然产物

Cat.No: T5654

Target: Others

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

Cat.No: T7190

Target: Apoptosis, Akt, JNK, Autophagy

Cat.No: TN1891

Target: Apoptosis, BCL, PARP, Caspase

Cat.No: TL0006

Synonym: 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid

Target: Reactive Oxygen Species, HIV Protease

Deoxyelephantopin

Cat.No: TN1079

Target: NF-κB

Cat.No: T6677

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Cat.No: T5S0896

Synonym: 龙血素 A,龙血素A

Target: Akt, PI3K

Cat.No: T5S0658

Synonym: 柯诺辛,柯诺辛碱

Target: Autophagy

Cat.No: T3844

Synonym: 三角叶薯蓣皂苷

Target: ERK, Others, Akt, Endogenous Metabolite

(Z)-Guggulsterone

Cat.No: T17280

Target: Apoptosis, VEGFR, Akt

Cat.No: TN1433

Target: FAK, Others, Akt

Cat.No: T5S1982

Synonym: Periplocoside,杠柳毒苷

Target: Apoptosis, Others

N-Oleoyl glycine

Cat.No: T13803

Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR

Cat.No: TN1644

Target: Others

Cat.No: T6S0781

Synonym: 黄柏碱,Phallodendrin

Target: Others, NF-κB, Akt

Isobavachalcone

Cat.No: T3861

Synonym: Corylifolinin,Isobacachalcone,补骨脂乙素

Target: Apoptosis, Others, Reactive Oxygen Species, Akt, Autophagy

Cat.No: T6817

Synonym: 鱼藤素,(-)-Deguelin,(-)-cis-Deguelin,魚藤素

Target: Apoptosis, Akt, PI3K, Autophagy

Cat.No: T2798

Synonym: 秦皮乙素,二羟基香豆素,Aesculetin,Cichorigenin

Target: Lipoxygenase, Akt, PI3K

Cat.No: T2791

Synonym: 柳穿鱼叶苷,大蓟苷

Target: Apoptosis, Others, NO Synthase, Prostaglandin Receptor, Interleukin

Cat.No: T7912

Synonym: (1R)-(-)-桃金娘烯醛,桃金娘烯醛,(1R)-(−)-Myrtenal

Target: Others

Cat.No: T5S0506

Synonym: Rutundic acid,铁冬青酸

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Cat.No: TN4761

Target: P-gp

Cat.No: TN1911

Synonym: 马里苷,马里甙

Target: transporter, Akt, HDAC, AMPK

Cat.No: T6S0619

Synonym: 3-O-Acetyltumulosic acid,茯苓酸

Target: ERK, Akt

Sophocarpine monohydrate

Cat.No: T2746

Synonym: 槐果碱,Sophocarpine,槐果碱水合物

Target: Apoptosis, Influenza Virus, Akt, PI3K, AMPK, Autophagy

Cat.No: T3895

Synonym: 重楼皂苷I,重楼皂甙

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

N-Feruloyloctopamine

Cat.No: TN1968

Synonym: N-Feruloyloctopamine,N-阿魏酰章鱼胺

Target: p38 MAPK, Akt

Cat.No: T5574

Synonym: Guggulsterone E&Z,香胶甾酮

Target: Apoptosis, FXR, Akt, Caspase, JNK, Autophagy

Cat.No: T2S0500

Synonym: 毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1

Target: Others

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: T0760

Synonym: Cholesterin,Cholesteryl alcohol,胆固醇

Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

Cat.No: T3001

Synonym: 和厚朴酚,NSC 293100

Target: ERK, HCV Protease, MEK, Akt, Autophagy

Cat.No: T0724

Synonym: Biochanin B,Flavosil,刺芒柄花素,Formononetol

Target: Apoptosis, FGFR

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Cat.No: T2789

Synonym: 黄岑素,野黄芩苷,Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide

Target: Akt, HIV Protease, STAT

Cat.No: T2790

Synonym: NSC-250682,Rubescenin,冬凌草甲素,Isodonol,Rubescensin A

Target: Akt, Antibacterial

Methyl Linoleate

Cat.No: T2P2810

Synonym: Linoleic acid methyl ester,亚油酸甲酯,Telfairic Acid methyl ester

Target: Antioxidant

25(R,S)-Ruscogenin

Cat.No: T5740

Synonym: (25RS)鲁斯可皂苷元,(25RS)-Ruscogenin

Target: Others, HIF

Cat.No: T4S21320

Synonym: 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮

Target: MMP, Others

Cyclovirobuxine D

Cat.No: T2974

Synonym: 黄杨碱,CVB-D,Bebuxine,Cyclovirobuxin D,环维黄杨星D

Target: Apoptosis, Others, Akt, mTOR, Autophagy

Cat.No: T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

Cat.No: TN3500

Synonym: β-Amyron,β-香树脂酮

Target: COX, AChR, PPAR, Antifection

Methacycline hydrochloride

Cat.No: T0518

Synonym: Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T13265

Synonym: 尿石素B,3-羟基-6H-苯并[C]苯并吡喃-6-酮

Target: ERK, NF-κB, Akt, Endogenous Metabolite, JNK, AMPK

Hederacolchiside A1

Cat.No: T2P2806

Synonym: 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

Cat.No: T3981

Synonym: 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

α-Linolenic acid

Cat.No: T3P2904

Synonym: Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸

Target: Akt, PI3K

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04552	AKT1 Protein, Human, Recombinant (His) RAC-ALPHA,v-akt murine thymoma viral oncogene homol...	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac...
TMPY-04574	AKT3 Protein, Mouse, Recombinant (aa 106-479, His & GST) v-akt murine thymoma viral oncogene homolog 3,Nmf35...	Mouse	Baculovirus Insect Cells
	AKT3 Protein, Mouse, Recombinant (aa 106-479, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 71 kDa and the accession number is Q9WUA6-1.
TMPY-04446	AKT3 Protein, Mouse, Recombinant (aa 106-479) D930002M15Rik,AI851531,Nmf350,v-akt murine thymoma ...	Mouse	Baculovirus Insect Cells
	AKT3 Protein, Mouse, Recombinant (aa 106-479) is expressed in Baculovirus insect cells. The predicted molecular weight is 43.4 kDa and the accession number is Q9WUA6-1.
TMPY-04387	AKT2 Protein, Human, Recombinant (His & GST) RAC-β,RAC-BETA,HIHGHH,PKBBETA,PKBβ,PRKBB,PKBB,v-akt...	Human	Baculovirus Insect Cells
	AKT (AK mouse plus Transforming or Thymoma) is a frequent oncogene expressed in most tissues which includes three isoforms AKT1, AKT2, and AKT3. Hyperactivation of AKT signaling is a central key in many human cancer progressions, through modulating angiogenesis, tumor growth, and cell migration, invasion, metastasis, and chemoresistance. Among all three isoforms, AKT2 is most related to cancer cell invasion, metastasis, and survival. Amplification and overexpression of AKT2 have been shown in ma...
TMPY-04553	AKT3 Protein, Human, Recombinant (GST) PRKBG,RAC-γ,RAC-PK-γ,MPPH,PKB-γ,PKBG,RAC-PK-gamma,STK-2,PKB-...	Human	Baculovirus Insect Cells
	AKT3 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 81 kDa and the accession number is Q9Y243-1.
TMPK-00474	IL-22RA1 Protein, Cynomolgus, Recombinant (His) CRF2-9,IL22R1,IL-22R-α-1,IL-22RA1,zcytoR11,IL22R,IL-22R-alph...	Cynomolgus	HEK293 Cells
	IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activatio...
TMPJ-00059	IL-7 Protein, Human, Recombinant (His) Interleukin-7,IL7,白细胞介素,IL-7,白介素	Human	HEK293 Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe...
TMPY-02518	TCL1A Protein, Human, Recombinant (His) TCL1,T-cell leukemia/lymphoma 1A	Human	E. coli
	T-cell leukemia/lymphoma protein 1A (abbreviated for TCL1A) is a member of the TCL1 family. TCL1 protooncogene is expressed in CD3-CD4-CD8-precursor T cells and is extinguished at the CD4+CD8+stage of thymocyte development. In B cells, TCL1 is first expressed in pro-B cells and remains high in naive mantle zone B cells of peripheral lymphoid tissues. The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. It has been demonstrated that TCL1 is a pow...
TMPH-01348	FSHR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is P23945.
TMPH-03365	REG3A Protein, Rat, Recombinant (E.coli, His)	Rat	E. coli
	Bactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Rat, Recombinant (E.coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.5 kDa and the accession number is P35231.
TMPH-01347	FSHR Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P23945.
TMPK-01263	B7-H7 Protein, Cynomolgus, Recombinant (His) B7H7,B7-H7,HHLA2,B7 Homolog 7	Cynomolgus	HEK293 Cells
	B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
TMPK-00136	ULBP-2 Protein, Human, Recombinant (His & Avi) ALCAN-α,RAET1L,NKG2D ligand 2,ALCAN-alpha,N2DL2,ULBP-2/5/6,R...	Human	HEK293 Cells
	ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity.
TMPH-02019	REG3A Protein, Human, Recombinant (GST)	Human	E. coli
	Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 43.6 kDa and the accession number is Q06141.
TMPH-01230	DIP2A Protein, Human, Recombinant (hFc) DIP2 homolog A,Disco-interacting protein 2 homolog A,KIAA018...	Human	HEK293 Cells
	Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes.
TMPH-01231	DIP2A Protein, Human, Recombinant (His) DIP2A,DIP2,Disco-interacting protein 2 homolog A,C21orf106,D...	Human	Baculovirus Insect Cells
	Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes.
TMPK-00723	RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) CD265,Rank,FEO,ODFR,NF-KB,OSTS,TNFRSF11A,OPTB7,NFKB,TRANCER,...	Mouse	HEK293 Cells
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 47.0 kDa and the acce...
TMPH-02842	CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO) CD133,Prom1,Prominin-like protein 1,Prom,Proml1,Antigen AC13...	Mouse	E. coli
	May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
TMPK-00732	WISP1/CCN4 Protein, Mouse, Recombinant (His) ELM-1,WISP1tc,WISP1c,CCN4,WISP-1,WISP1i	Mouse	HEK293 Cells
	The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.
TMPK-01034	SEMA4B Protein, Mouse, Recombinant (His) SEMA4B,SemC,Semaphorin-C,MGC131831,Semaphorin-4B,KIAA1745,SE...	Mouse	HEK293 Cells
	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.
TMPH-01559	IL-26 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecula...
TMPK-00925	Noggin/NOG Protein, Mouse, Recombinant NOG,SYM1,SYNS1,Noggin	Mouse	HEK293 Cells
	Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt. Noggin/NOG...
TMPK-00351	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) NF-KB,ODFR,PDB2,Rank,OSTS,NFKB,OPTB7,TNFRSF11A,LOH18CR1,CD26...	Human	HEK293 Cells
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.85 kDa ...
TMPK-00926	Noggin/NOG Protein, Mouse, Recombinant (His & Flag) SYNS1,NOG,SYM1,Noggin	Mouse	HEK293 Cells
	Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt. Noggin/NOG...
TMPH-00001	CD133/PROM1 Protein-VLP, Human, Recombinant (His) Proml1,Prom1,CD133,Prominin-like protein 1,Antigen AC133 hom...	Human	HEK293 Cells
	May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. CD133/PROM1 Protein...
TMPH-01560	IL-26 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-T...
TMPY-02398	TLE3 Protein, Human, Recombinant (aa 484-772, GST) transducin-like enhancer of split 3,GRG3,ESG3,HsT18976,ESG	Human	E. coli
	The association between high TLE3 expression and a favorable response to taxane-containing chemotherapy regimens was validated in patients with non-serous ovarian cancer. That TLE3 expression may serve as a marker of chemosensitivity in taxane-treated patients with non-serous histologies. Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds of cancers. TLE3 repressed CRC proliferation partly thro...
TMPY-04899	OGN/Osteoglycin Protein, Human, Recombinant (His) OIF,OG,osteoglycin,SLRR3A	Human	HEK293 Cells
	OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor-beta and may regulate osteoblast differentiation. OGN is broadly expressed in the gall bladder, endometrium, and other tissues. OGN reduced Zeb-1 expression via EGFR/Akt leading to inhibition of epith...
TMPH-02878	PTPRS Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteo...
TMPJ-00181	PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated Programmed cell death protein 1,PDCD1,CD279,hPD-1	Human	HEK293 Cells
	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been sugg...
TMPH-01540	Intelectin-1/ITLN1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not ...
TMPJ-00978	PIP4K2A Protein, Human, Recombinant (His) Diphosphoinositide kinase 2-α,PtdIns(5)P-4-kinase isoform 2-...	Human	HEK293 Cells
	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the...
TMPY-01576	Artemin Protein, Mouse, Recombinant (hFc) artemin,neublastin	Mouse	HEK293 Cells
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. It a...
TMPJ-00674	RANK/TNFRSF11A Protein, Mouse, Recombinant (His) Receptor activator of NF-KB,TNFRSF11A,Osteoclast differentia...	Mouse	HEK293 Cells
	Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br...
TMPY-05250	CLEC3A Protein, Mouse, Recombinant (His) C-type lectin domain family 3, member A,Gm796,1110019O10Rik,...	Mouse	Baculovirus Insect Cells
	C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicated a poor prognosis in breast IDC. CLEC3A knockdown inhibited BC cell growth and metastasis might be through suppressing PI3K/AKT signaling activity. That CLEC3A is a promising therapeutic target for BC in the future. Matrilysin (MMP-7) plays important roles in tumor progression. ...
TMPY-04461	TRIB3 Protein, Human, Recombinant (GST) SKIP3,C20orf97,tribbles pseudokinase 3,TRB3,SINK,NIPK	Human	Baculovirus Insect Cells
	Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family and Tribbles subfamily. Highest expression Of TRIB3 is in liver, pancreas, peripheral blood leukocytes and bone marrow. It is also highly expressed in a number of primary lung, colon and breast tumors. TRIB3 is expressed in spleen, thymus, and prostate an...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His) eIF5AII,eukaryotic translation initiation factor 5A2,EIF-5A2	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe...
TMPY-04484	ACK1 Protein, Human, Recombinant (GST) ACK-1,ACK1,p21cdc42Hs,ACK,tyrosine kinase, non-receptor, 2	Human	Baculovirus Insect Cells
	ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell migration via phosphorylation of BCAR1. The ACK1 protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. ACK1 integrates signals from plethora of liga...
TMPY-04562	GRK2 Protein, Human, Recombinant (His & GST) β,adrenergic, beta, receptor kinase 1	Human	Baculovirus Insect Cells
	G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been repor...
TMPY-04084	ANGPTL1 Protein, Canine, Recombinant (hFc) angiopoietin-like 1	Canine	HEK293 Cells
	Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC).The downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decre...

重组蛋白

AKT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

AKT3 Protein, Mouse, Recombinant (aa 106-479, His & GST)

Cat.No: TMPY-04574

Species: Mouse

Expression System: Baculovirus Insect Cells

AKT3 Protein, Mouse, Recombinant (aa 106-479)

Cat.No: TMPY-04446

Species: Mouse

Expression System: Baculovirus Insect Cells

AKT2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04387

Species: Human

Expression System: Baculovirus Insect Cells

AKT3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04553

Species: Human

Expression System: Baculovirus Insect Cells

IL-22RA1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00474

Species: Cynomolgus

Expression System: HEK293 Cells

IL-7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00059

Species: Human

Expression System: HEK293 Cells

TCL1A Protein, Human, Recombinant (His)

Cat.No: TMPY-02518

Species: Human

Expression System: E. coli

FSHR Protein, Human, Recombinant (His)

Cat.No: TMPH-01348

Species: Human

Expression System: HEK293 Cells

REG3A Protein, Rat, Recombinant (E.coli, His)

Cat.No: TMPH-03365

Species: Rat

Expression System: E. coli

FSHR Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01347

Species: Human

Expression System: E. coli

B7-H7 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01263

Species: Cynomolgus

Expression System: HEK293 Cells

ULBP-2 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00136

Species: Human

Expression System: HEK293 Cells

REG3A Protein, Human, Recombinant (GST)

Cat.No: TMPH-02019

Species: Human

Expression System: E. coli

DIP2A Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01230

Species: Human

Expression System: HEK293 Cells

DIP2A Protein, Human, Recombinant (His)

Cat.No: TMPH-01231

Species: Human

Expression System: Baculovirus Insect Cells

RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00723

Species: Mouse

Expression System: HEK293 Cells

CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02842

Species: Mouse

Expression System: E. coli

WISP1/CCN4 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00732

Species: Mouse

Expression System: HEK293 Cells

SEMA4B Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01034

Species: Mouse

Expression System: HEK293 Cells

IL-26 Protein, Human, Recombinant (His)

Cat.No: TMPH-01559

Species: Human

Expression System: P. pastoris (Yeast)

Noggin/NOG Protein, Mouse, Recombinant

Cat.No: TMPK-00925

Species: Mouse

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)

Cat.No: TMPK-00351

Species: Human

Expression System: HEK293 Cells

Noggin/NOG Protein, Mouse, Recombinant (His & Flag)

Cat.No: TMPK-00926

Species: Mouse

Expression System: HEK293 Cells

CD133/PROM1 Protein-VLP, Human, Recombinant (His)

Cat.No: TMPH-00001

Species: Human

Expression System: HEK293 Cells

IL-26 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPH-01560

Species: Human

Expression System: E. coli

TLE3 Protein, Human, Recombinant (aa 484-772, GST)

Cat.No: TMPY-02398

Species: Human

Expression System: E. coli

OGN/Osteoglycin Protein, Human, Recombinant (His)

Cat.No: TMPY-04899

Species: Human

Expression System: HEK293 Cells

PTPRS Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02878

Species: Mouse

Expression System: E. coli

PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00181

Species: Human

Expression System: HEK293 Cells

Intelectin-1/ITLN1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01540

Species: Human

Expression System: E. coli

PIP4K2A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00978

Species: Human

Expression System: HEK293 Cells

Artemin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01576

Species: Mouse

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00674

Species: Mouse

Expression System: HEK293 Cells

CLEC3A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05250

Species: Mouse

Expression System: Baculovirus Insect Cells

TRIB3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04461

Species: Human

Expression System: Baculovirus Insect Cells

EIF5A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03795

Species: Human

Expression System: E. coli

ACK1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04484

Species: Human

Expression System: Baculovirus Insect Cells

GRK2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04562

Species: Human

Expression System: Baculovirus Insect Cells

ANGPTL1 Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-04084

Species: Canine

Expression System: HEK293 Cells

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