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Anti-Phospho-Akt (Thr308) Antibody (4U466)
还可以产品编号 TMAY-01559
Anti-Phospho-Akt (Thr308) Antibody (4U466) 是一种 Rabbit 抗体，靶向 Phospho-Akt (Thr308)。Anti-Phospho-Akt (Thr308) Antibody (4U466) 可用于 WB。
Anti-Phospho-Akt (Thr308) Antibody (4U466)
Anti-Phospho-Akt (Thr308) Antibody (4U466)
还可以产品编号 TMAY-01559
Anti-Phospho-Akt (Thr308) Antibody (4U466) 是一种 Rabbit 抗体，靶向 Phospho-Akt (Thr308)。Anti-Phospho-Akt (Thr308) Antibody (4U466) 可用于 WB。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-Akt (Thr308) Antibody (4U466) is a Rabbit antibody targeting Phospho-Akt (Thr308). Anti-Phospho-Akt (Thr308) Antibody (4U466) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4U466 |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of extracts from serum-starved NIH-3T3, untreated (line A); treated with PDGFA (5 μg/mL, 5 min) (line B) using Phospho-AKT (Ser308) rabbit monoclonal Antibody at 1:5000 dilution. 2. Western blot analysis of extracts from serum-starved NIH 3T3, untreated (line A); treated with PDGFA (5 μg/mL, 5 min; +) (line B); treated with PDGFA and λ-phosphatase (line C) using Phospho-AKT (Thr308) rabbit monoclonal Antibody at 1:1000 dilution. |
| 应用 | WB |
| 推荐剂量 | WB: 1:1000-1:5000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the residues around Thr308 of Human Phospho-Akt. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| 研究背景 | v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 activity was found to antagonize pathologic cardiac growth that occurs in response to endothelin 1 stimulation or pressure overload. AKT1 selectively promotes physiological cardiac growth while AKT2 selectively promotes insulin-stimulated cardiac glucose metabolism. AKT1 deletion prevented tumor initiation as well as tumor progression, coincident with decreased Akt signaling in tumor tissues. AKT1 is the primary Akt isoform activated by mutant K-ras in lung tumors, and that AKT3 may oppose AKT1 in lung tumorigenesis and lung tumor progression. A number of separate studies have implicated AKT1 as an inhibitor of breast epithelial cell motility and invasion. AKT1 may have a dual role in tumorigenesis, acting not only pro-oncogenically by suppressing apoptosis but also anti-oncogenically by suppressing invasion and metastasis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the residues around Ser308 of Human Phospho-Akt |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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