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顶部生物活性储存和溶解信息计算器

Anti-Phospho-AKT (Thr308) Antibody (4U466)

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Anti-Phospho-AKT (Thr308) Antibody (4U466)
产品编号 TMAY-01559
别名 RAC-ALPHA, RAC, PRKBA, PKB-ALPHA, PKB, Phospho-Akt (T308), p-Akt (Thr308), p-Akt (T308), Akt (p-Thr308), Akt (p-T308), AKT

Anti-Phospho-AKT (Thr308) Antibody (4U466) 是一种 Rabbit 抗体，靶向 Phospho-AKT (Thr308)。Anti-Phospho-AKT (Thr308) Antibody (4U466) 可用于 WB。

Anti-Phospho-AKT (Thr308) Antibody (4U466)
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Anti-Phospho-AKT (Thr308) Antibody (4U466)

Rating icon 还可以
Anti-Phospho-AKT (Thr308) Antibody (4U466)
产品编号 TMAY-01559 别名 RAC-ALPHA, RAC, PRKBA, PKB-ALPHA, PKB, Phospho-Akt (T308), p-Akt (Thr308), p-Akt (T308), Akt (p-Thr308), Akt (p-T308), AKT

Anti-Phospho-AKT (Thr308) Antibody (4U466) 是一种 Rabbit 抗体，靶向 Phospho-AKT (Thr308)。Anti-Phospho-AKT (Thr308) Antibody (4U466) 可用于 WB。

规格价格库存数量
20 μL
¥ 679
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100 μL
¥ 1,989
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-AKT (Thr308) Antibody (4U466) is a Rabbit antibody targeting Phospho-AKT (Thr308). Anti-Phospho-AKT (Thr308) Antibody (4U466) can be used in WB.
别名RAC-ALPHA, RAC, PRKBA, PKB-ALPHA, PKB, Phospho-Akt (T308), p-Akt (Thr308), p-Akt (T308), Akt (p-Thr308), Akt (p-T308), AKT
Ig Type
Rabbit IgG
克隆号
4U466
交叉反应
Human
验证活性
1. Western blot analysis of extracts from serum-starved NIH-3T3, untreated (line A); treated with PDGFA (5 μg/mL, 5 min) (line B) using Phospho-AKT (Ser308) rabbit monoclonal Antibody at 1:5000 dilution.
2. Western blot analysis of extracts from serum-starved NIH 3T3, untreated (line A); treated with PDGFA (5 μg/mL, 5 min; +) (line B); treated with PDGFA and λ-phosphatase (line C) using Phospho-AKT (Thr308) rabbit monoclonal Antibody at 1:1000 dilution.
应用
WB
推荐剂量
WB: 1:1000-1:5000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the residues around Thr308 of Human Phospho-Akt.
纯化方式Protein A
性状Liquid
缓冲液10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
研究背景v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 activity was found to antagonize pathologic cardiac growth that occurs in response to endothelin 1 stimulation or pressure overload. AKT1 selectively promotes physiological cardiac growth while AKT2 selectively promotes insulin-stimulated cardiac glucose metabolism. AKT1 deletion prevented tumor initiation as well as tumor progression, coincident with decreased Akt signaling in tumor tissues. AKT1 is the primary Akt isoform activated by mutant K-ras in lung tumors, and that AKT3 may oppose AKT1 in lung tumorigenesis and lung tumor progression. A number of separate studies have implicated AKT1 as an inhibitor of breast epithelial cell motility and invasion. AKT1 may have a dual role in tumorigenesis, acting not only pro-oncogenically by suppressing apoptosis but also anti-oncogenically by suppressing invasion and metastasis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: residues around Ser308 of Human Phospho-Akt
抗原种属
Human
研究领域
Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

pAkt (Thr308)pAkt (T308)Akt (pThr308)Akt (pT308)Akt (phospho-Thr308)Akt (phospho-T308)

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4个月前
5.0
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