Gambogic amide is a potent and selective agonist of tropomyosin receptor kinase A (TrkA) that promotes tyrosine phosphorylation and activates downstream signaling pathways including Akt and MAPK. Gambogic amide specifically binds to the cytoplasmic juxtamembrane domain of the TrkA receptor, thereby stimulating receptor dimerization and activation. Gambogic amide has been reported to prevent glutamate-induced neuronal cell death and demonstrates enhanced activity in a transient middle cerebral artery occlusion model of stroke. These biological properties support the utilization of Gambogic amide in research focused on neurodegenerative disorders, neuronal survival mechanisms, neurotrophic signaling pathways, and ischemic brain injury.

藤黄酰胺