Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ipatasertib-NH2 dihydrochloride is a ligand for the target protein AKT in PROTAC INY-03-041. INY-03-041 consists of Ipatasertib-NH2, a ten-hydrocarbon linker, and the CRBN ligand Lenalidomide, which acts as an E3 ubiquitin ligase.
产品描述 | Ipatasertib-NH2 dihydrochloride is a ligand for the target protein AKT in PROTAC INY-03-041. INY-03-041 consists of Ipatasertib-NH2, a ten-hydrocarbon linker, and the CRBN ligand Lenalidomide, which acts as an E3 ubiquitin ligase. |
体外活性 | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
别名 | RG7440-NH2 dihydrochloride, Ipatasertib-NH2 dihydrochloride, GDC-0068-NH2 dihydrochloride |
分子量 | 488.84 |
分子式 | C21H28Cl3N5O2 |
CAS No. | 1001264-73-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ipatasertib-NH2 dihydrochloride 1001264-73-8 RG7440-NH2 dihydrochloride IpatasertibNH2 dihydrochloride RG7440-NH2 GDC-0068-NH2 Dihydrochloride GDC-0068-NH2 Ipatasertib NH2 dihydrochloride GDC-0068-NH2 dihydrochloride Ipatasertib-NH2 Ipatasertib-NH-2 dihydrochloride RG7440-NH2 Dihydrochloride Ipatasertib-NH2 Dihydrochloride Inhibitor inhibitor inhibit