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TargetMol | Compound Library

神经信号分子库现货

Neuronal Signaling Compound Library

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产品编号 L2600

神经元之间和神经元内部的通信对于神经系统的所有功能至关重要,无论是从发育到衰老,还是从健康到疾病。在过去十年中,我们对神经系统内分子、细胞和系统信号通路的认识取得了巨大进步,在信号通路研究方面取得了重大突破,这些神经信号通路是神经发生、成瘾、自闭症以及情绪障碍的病理生理学和治疗基础。例如:G 蛋白偶联受体(GPCR),包括5-HT 受体、组胺受体、阿片受体等,是研究较多的神经元信号传导途径,GPCR 功能障碍会引起多种神经疾病;Notch 信号途径调节神经干细胞增殖、存活、自我更新和分化,Notch 信号传导异常参与中风、阿尔茨海默病和CNS 肿瘤等疾病中发生的病理过程。因此靶向神经元信号传导,可以用来治疗多种不同CNS 疾病。

TargetMol 神经信号分子库包含2771 种神经信号相关的小分子化合物,主要用于神经系统类疾病的药物研发,可用于高通量、高内涵筛选。

TargetMol 的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
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产品编号 L2600

神经信号分子库

规格

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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产品描述 产品描述

  • 2771种CNS相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
  • 靶点包括5-HT receptor、AChR、Histamine receptor、dopamine receptor、Opiod receptor等;
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

包装和储存 包装和储存

  • 可选用DMSO耐受的96/384孔板或2D 条形码编码管;
  • 干粉蓝冰运输,DMSO溶液干冰运输;
  • 排布:96孔板:1st & 12th 空白对照,384孔板:1st & 2nd & 23th & 24th空白对照。
  • 本化合物库通常以 DMSO 10 mM 浓度提供。少量产品可能因溶解性或稳定性需求,采用其他溶剂或浓度包装,具体以实际产品信息为准。

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Library Customization | TargetMol 化合物库组成

5-HT Receptor
AChR
Adrenergic Receptor
COX
Dopamine Receptor
Apoptosis
Calcium Channel
Histamine Receptor
GABA Receptor
iGluR
GluR
Endogenous Metabolite
Autophagy
TRP/TRPV Channel
Cholinesterase (ChE)
Adenosine Receptor
NMDAR
Opioid Receptor
Antibacterial
NF-κB
MAO
Monoamine Oxidase
Beta Amyloid
ROS
Parasite
Potassium Channel
Serotonin Transporter
P-gp
Gamma-secretase
Cannabinoid Receptor
Sodium Channel
P2X Receptor
CaMK
Norepinephrine
Akt
NO Synthase
ERK
Reactive Oxygen Species
FAAH
Cytochromes P450
TNF
Interleukin
Neurokinin receptor
Caspase
p38 MAPK
Sigma receptor
PDE
Drug Metabolite
GPCR
PPAR
Lipoxygenase
Influenza Virus
Antibiotic
PI3K
P2Y Receptor
BACE
OX Receptor
Neuropeptide Y Receptor
HIV Protease
Beta-Secretase
Antioxidant
Prostaglandin Receptor
Antifungal
NOS
Ferroptosis
MMP
DNA/RNA Synthesis
SARS-CoV
Virus Protease
IL Receptor
Bcl-2 Family
JNK
Melatonin Receptor
Wnt/beta-catenin
PKC
STAT
VEGFR
EGFR
Phospholipase
Imidazoline Receptor
Mitophagy
Mitochondrial Metabolism
PGE Synthase
Adenylyl Cyclase
Phosphatase
GSK-3
PKA
MT Receptor
GlyT
mTOR
TLR
IκB/IKK
AMPK
Anti-infection
Dehydrogenase
Nrf2
Chloride channel
Carbonic Anhydrase
Transferase
Histone Methyltransferase
HCV Protease
Estrogen/progestogen Receptor
PERK
Glucocorticoid Receptor
CDK
Monoamine Transporter
HSV
TGF-beta/Smad
Melanocortin Receptor
MEK
CGRP Receptor
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
IFNAR
Histone Demethylase
MRP
AAK1
Nucleoside Antimetabolite/Analog
Leukotriene Receptor
Hydroxylase
ATPase
Src
Amino Acids and Derivatives
NADPH
RAAS
Glutathione Peroxidase
HBV
Cholecystokinin Receptor
PARP
Serine/threonin kinase
Immunology/Inflammation related
Neuropeptide FF Receptor
PAFR
AAK1 (AP2 associated kinase 1)
ABC Transporter
Glucosidase
JAK
CCR
Angiotensin-converting Enzyme (ACE)
Epigenetic Reader Domain
glycosidase
Trk receptor
transporter
HDAC
Microtubule Associated
NOD-like Receptor (NLR)
Melanin-concentrating Hormone Receptor (MCHR)
Na+/Ca2+ Exchanger
Reductase
Lipase
Neurotensin Receptor
Topoisomerase
UGT
Antifection
Epoxide Hydrolase
cAMP
IGF-1R
MAPK
Acyltransferase
FOXO
MDM-2/p53
FAK
Thyroid hormone receptor(THR)
Advanced Glycation End Products
Transaminase
Monocarboxylate transporter
Integrin
c-Met/HGFR
Arrestin
DYRK
MIF
Progesterone Receptor
Estrogen Receptor/ERR
ROCK
Aryl Hydrocarbon Receptor
IAP
Bcr-Abl
LDL
MAGL
PTEN
Aurora Kinase
DNA
Androgen Receptor
BCRP
HSP
STING
Sirtuin
GluCls
RSV
ATM/ATR
GST
Oxytocin Receptor
FGFR
Gap Junction Protein
Platelet aggregation
DNA Methyltransferase
NOD
IRAK
Ras
S6 Kinase
ROS Kinase
CFTR
p53
FOXO3
Proteasome
Taste receptor
MicroRNA
CAT
ROR
LPL Receptor
Glutaminyl Cyclase
LTR
Neuropeptide W
Necroptosis
gp120/CD4
GTPase
OCT
c-Myc
Galectin
N-Acetylglucosaminyltransferase
CaSR
ASCT
Serine Protease
Antifolate
Cell Cycle Arrest
Cysteine Protease
Liver X Receptor
LIM Kinase
FXR
Glutaminase
LDLR
NR4A
IDO
Prolyl Endopeptidase (PREP)
Myosin
Annexin A
FLAP
RIP kinase
Adiponectin Receptor
Raf
Glucagon Receptor
Anion Exchanger
HCN Channel
Fatty Acid Synthase
Hedgehog/Smoothened
Bombesin Receptor
PAK
PDGFR
Stearoyl-CoA Desaturase (SCD)
ACK1
CXCR
Somatostatin
Orphan Receptor
Indoleamine 2,3-Dioxygenase (IDO)
SGLT
ATP Citrate Lyase
Lipid
OXPHOS
Antiviral
Free radical scavengers
Aminopeptidase
GPCR19
Ephrin Receptor
CD74
Pyroptosis
Casein Kinase
Carboxypeptidase
Reverse Transcriptase
Retinoid Receptor
CRISPR/Cas9
Adenosine Deaminase
FLT
Syk
NADPH-oxidase
HMG-CoA Reductase
Thrombin
Protease-activated Receptor
Lysosomal Autophagy
Liposome
AhR
PD-1/PD-L1
S1P Receptor
NMU2R
NMUR