nfκb

CHPG hydrochloride 是 mGluR5 的选择性激动剂。

Antiproliferative agent-22 是一种抗癌化合物，在 MCF-7、MDA-MB-231 和 MDA-MB-468 细胞上显示出抗增殖活性。Antiproliferative agent-22 可用于研究癌症。

BHA536 作为一种口服有效的PKCα/β与NF-kB信号通路抑制剂，它能够抑制携带 CD79 变异的 ABC DLBCL 细胞的增殖，通过在 G1 期阻滞细胞周期，以及诱导 TMD8 细胞的凋亡 (apoptosis) 来发挥作用。此外，BHA536 在小鼠模型中显示出显著的抗肿瘤活性。

Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-κB.

2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and make a contribution to further understanding the pharmaceutical activity of Eupatorium plants.

Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.

Isosalvianolic acid B is a natural from Salviae miltiorrhizae

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant

Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is endowed with estrogenic properties accounting, at least in part, for E. lysistemon effects. Alp

Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-κB signaling.

Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammato

Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid (

Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.L

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act

Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.

Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.

iNOS/TopoI-IN-1（compound AuL9）是一种具备多重靶点的杂交分子，表现出抗肿瘤、抗炎及抗氧化的特性。此化合物能有效抑制乳腺癌细胞株MCF-7和MDA MB-231的增长，IC50分别为3.5 μM及6.3 μM，其机制主要是通过抑制人类拓扑异构酶I（TopoI）（Ki=2.72 μM）的活动，导致DNA损伤并诱发细胞凋亡（apoptosis）。同时，iNOS/TopoI-IN-1通过降低NF-kB的激活，抑制iNOS表达（Ki=1.49 μM），进一步增强其抗炎作用。

Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as ini

COX-2-IN-48 (5-25) 为一种针对COX-2的抑制剂，在人类COX-2上的IC50值为51.7 nM。它通过干预NF-κB通路，在多种啮齿类动物模型中展现了其抗炎及镇痛的效果。此外，COX-2-IN-48 (5-25) 能够抑制IκB的降解、NF-κB p65的磷酸化及其核内转移，同时抑制COX-2和iNOS的表达。

Anti-osteoporosis agent-11 (compound 3k) 是一种能够靶向并抑制破骨细胞分化的抗骨质疏松化合物，其中对破骨细胞的抑制效果尤为显著，表现在其 IC50 值为 0.36 μM。此化合物还能通过阻断rankl诱导的丝裂原活化蛋白激酶 (MAPK) 和NF-κB信号通路来抑制破骨细胞的形成、骨质吸收以及破骨细胞特异性基因的表达，显示出其潜在的医疗应用价值。

NLRP3-IN-51（Compound 3q）作为一种高效的胆碱能抗炎通路（CAP）激活剂，显示了在THP-1细胞中抑制由尿酸钠（MSU）诱导的IL-1β产生，有助于抗痛风性关节炎。该化合物同样抑制了MSU诱导的NF-κBp65磷酸化，而对NLRP3、pro-caspase 1以及caspase-1的自我裂解与激活则无明显影响。据此，NLRP3-IN-51在CAP的激活下有效抑制NLRP3的活化初期。

oxLig-1（7-Ketocholesteryl-9-carboxynonanoate）作为氧化低密度脂蛋白 (oxLDL) 中的关键脂质成分，兼具 β-糖蛋白 I （β(2)-GPI）的主要配体功能。它通过激活NF-κB通路引发核的易位，进而在动脉粥样硬化（AS）的研究中发挥作用。

RIPK2-IN-6 (Compound 15a) 作为RIPK的抑制剂，能够有效阻断RIPK2的磷酸化作用，进而抑制NF-κB及MAPK信号通路。此化合物在Dextran sodium sulfate诱导的小鼠结肠炎模型中展示了显著的抗炎和抗纤维化效果。

AP-1/NF-κB activation inhibitor 1 是一种有效的 AP-1和 NF-κB 介导的转录激活抑制剂(IC50=1 μM)，不阻断 β-actin 启动子驱动的基础转录。AP-1/NF-κB activation inhibitor 1 对受刺激细胞中 IL-2和 IL-8的产生水平有相似的抑制作用。